(Z)-3-(5-bromofuran-2-ylmethylene)-1-(4-bromophenyl)-4-phenylazetidin-2-one | 1125691-38-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 英文名称: (Z)-3-(5-bromofuran-2-ylmethylene)-1-(4-bromophenyl)-4-phenylazetidin-2-one
• 英文别名: (3Z)-3-[(5-bromofuran-2-yl)methylidene]-1-(4-bromophenyl)-4-phenylazetidin-2-one
• CAS: 1125691-38-4
• 化学式: C₂₀H₁₃Br₂NO₂
• 分子量: 459.137
• InChiKey: MPBSDOUHBFQDLN-ATVHPVEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  33.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-溴-2-呋喃甲醛 、 cis-1-(4-bromophenyl)-4-phenyl-3-(trimethylsilyl)azetidin-2-one 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 生成 (E)-3-(5-bromofuran-2-ylmethylene)-1-(4-bromophenyl)-4-phenylazetidin-2-one 、 (Z)-3-(5-bromofuran-2-ylmethylene)-1-(4-bromophenyl)-4-phenylazetidin-2-one
  参考文献：
  名称：

  β-Lactam derivatives as potential anti-cancer compounds

  摘要：

  A number of 1,4-diaryl-3-methylene substituted beta-lactams, the addition products obtained from their reactions with N-, S-, and C-nucleophiles, and diverse related compounds were prepared, and a selection of 43 compounds was screened in preliminary tests as anti-tumor compounds by using 4 or 5 human cancer cell lines of diverse origins. Twelve compounds were highly active against all cell lines, 6 showed low activity, 12 no activity, and 13 exhibited a selective activity against a human small cell lung carcinoma cell line.

  DOI：

  10.1007/s00706-007-0838-4

文献信息

• β-Lactam derivatives as potential anti-cancer compounds
  作者：Sabine Ruf、Gerd Neudert、Susanne Gürtler、Renate Grünert、Patrick J. Bednarski、Hans-Hartwig Otto

  DOI：10.1007/s00706-007-0838-4

  日期：2008.7

  A number of 1,4-diaryl-3-methylene substituted beta-lactams, the addition products obtained from their reactions with N-, S-, and C-nucleophiles, and diverse related compounds were prepared, and a selection of 43 compounds was screened in preliminary tests as anti-tumor compounds by using 4 or 5 human cancer cell lines of diverse origins. Twelve compounds were highly active against all cell lines, 6 showed low activity, 12 no activity, and 13 exhibited a selective activity against a human small cell lung carcinoma cell line.