4-methyl-2,6-bis-[(2-morpholin-4-yl-ethylimino)-methyl]-phenol | 1163155-76-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-methyl-2,6-bis-[(2-morpholin-4-yl-ethylimino)-methyl]-phenol
• 英文别名: 4-Methyl-2,6-bis(2-morpholin-4-ylethyliminomethyl)phenol
• CAS: 1163155-76-7
• 化学式: C₂₁H₃₂N₄O₃
• 分子量: 388.51
• InChiKey: YWGACJBVNYWKLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  69.9
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-methyl-2,6-bis-[(2-morpholin-4-yl-ethylimino)-methyl]-phenol 、 zinc(II) chloride 以 乙腈 为溶剂， 以68%的产率得到trichloro(4-methyl-2,6-bis(1-(2-morpholinoethyl)iminomethyl)-phenolato)zinc(II)
  参考文献：
  名称：

  Synthesis, characterization and selective fluorescent zinc(II) sensing property of three Schiff-base compounds

  摘要：

  Three Schiff-base compounds, 4-methyl-2,6-bis(1-(2-piperidinoethyl)iminomethyl)-phenol (HL1), 4-methyl-2,6-bis( 1-(2-pyrrolidinoethyl)-iminomethyl)-phenol (HL2) and (4-methyl-2,6-bis(1-(2- morpholinoethyl) iminomethyl)-phenol) (HL3), have been synthesized and characterized by elemental analysis, FT-IR, H-1 NMR, UV-Vis, electrospray ionisation mass and fluorescence spectroscopy. The emission quantum yield of the compounds increases by ca. 10-17 times by the addition of Zn2+ ion. Introduction of other metal ions of biological and environmental relevance either keeps unaltered or quenches the emission intensity of the ligands. This happens because of large binding constant (similar to 10(4) M-1) of the ligand with Zn2+ ion in acetonitrile. Each of the three ligands forms 1: 2 (ligand: metal) complexes which are characterized by single crystal X-ray diffraction analyses. This imposes rigidity to the ligand due to the complexation and, as a result, the radiative decay constant increases and the corresponding nonradiative decay parameter decreases. All of the ligands react with zinc chloride in acetonitrile to form dinuclear complexes which have been characterized by the elemental analysis, FT-IR, UV-Vis, electrospray ionisation mass spectroscopies and single crystal X-ray structural determinations. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2009.01.023
• 作为产物：
  描述：

  N-(2-氨基乙基)吗啉 、 2,6-二甲酰-4-甲基苯酚 以 乙腈 为溶剂， 反应 4.0h， 生成 4-methyl-2,6-bis-[(2-morpholin-4-yl-ethylimino)-methyl]-phenol
  参考文献：
  名称：

  一种新的酚基桥联双核锰（II）络合物作为通过Mn 2+离子置换的Zn 2+离子开启氟传感器

  摘要：

  一种新的合成且具有结构特征的酚基桥联双核锰（II）配合物，配制成[Mn 2 L（OAc）2（DMF）2 ] PF 6（1）（其中HL =  4-甲基-2,6-bis - [（2-吗啉-4-基-乙基亚氨基） -甲基] -苯酚和OAC =乙酸根阴离子），可以作为一个起作用接通的Zn 2+感测探针通过原位相应的双核Zn中形成（II）通过直接Mn 2+形成[Zn 2 L（OAc）2 ] PF 6（2）络合物在MeOH / DMF（1/14）介质中进行离子置换。由于向溶液1中添加Zn 2+离子而产生的选择性和特异性荧光变化，使得能够检测二甲基甲酰胺（DMF）中的Zn 2+离子。荧光双核锌（II）络合物2也已经通过Zn 2+离子与HL之间的直接反应生成。1号和2号复合体通过使用物理化学和光谱学工具进行表征，最后通过单晶X射线晶体学进行详细的结构测定。晶体学研究表明，配合物中的Mn（II）和Zn（II）

  DOI：

  10.1016/j.poly.2021.115226

文献信息

• Synthesis, characterization and catalytic activities towards epoxidation of olefins of dinuclear copper(II) complexes
  作者：Shibashis Halder、Aparajita Mukherjee、Koushik Ghosh、Sudipto Dey、Mahasweta Nandi、Partha Roy

  DOI：10.1016/j.molstruc.2015.08.017

  日期：2015.12

  analysis reveals that in both the complexes, two copper atoms are linked by phenoxo oxygen atom and a bridging ligand, namely chloride and azide, respectively. These complexes have been used as catalyst for the epoxidation of cyclohexene, styrene, α-methyl styrene, trans-stilbene and norbornene using tert-butyl hydroperoxide as the oxidant in acetonitrile under mild conditions. All of the substrates undergo

  摘要 两种铜 (II) 配合物 [Cu2(L1)Cl3].2H2O (1) 和 [Cu2(L2)(N3)CL2] (2) 其中 HL1 = 4-methyl-2,6-bis((2- morpholinoethylimino)methyl)phenol 和 HL2 = 4-methyl-2,6-bis((3-morpholinopropylimino)methyl)phenol 已经合成并通过元素分析、各种光谱方法、TGA 和单晶 X 射线衍射分析表征。单晶 X 射线衍射分析表明，在这两种配合物中，两个铜原子分别通过苯氧氧原子和桥连配体（即氯化物和叠氮化物）连接。这些配合物已被用作在温和条​​件下在乙腈中使用叔丁基过氧化氢作为氧化剂环氧化环己烯、苯乙烯、α-甲基苯乙烯、反式二苯乙烯和降冰片烯的催化剂。
• A phenolato-bridged dinuclear Ni(II) complex for selective fluorescent sensing of oxalate in aqueous medium
  作者：Ayan Patra、Sujaya Chakraborty、Somenath Lohar、Ennio Zangrando、Pabitra Chattopadhyay

  DOI：10.1016/j.ica.2021.120493

  日期：2021.9

  A newly synthesized and characterized phenolato bridged di-nuclear nickel(II) complex (1) acts as a highly sensitive chemosensor for aqueous oxalate ions in water/DMSO (29:1, v/v) medium. Gradual addition of aqueous oxalate ions to complex 1 led to the in situ formation of L−(4-methyl-2,6-bis-[(2-morpholin-4-yl-ethylimino)-methyl]-phenolate) anion, which shows a single point fluorescence enhancement

  一种新合成和表征的苯酚桥连双核镍 (II) 配合物 ( 1 ) 可用作水/DMSO (29:1, v/v) 介质中草酸根离子水溶液的高灵敏度化学传感器。将草酸水溶液逐渐添加到配合物1 中导致 L - (4-methyl-2,6-bis-[(2-morpholin-4-yl-ethylimino ) -methyl]-phenolate ) 阴离子的原位形成，其中显示了基于分子内电荷转移 (ICT) 的 528 nm 单点荧光增强，并表现出优于其他竞争性阴离子的潜在开启荧光特性。紫外-可见光谱、质谱和单晶 X 射线衍射研究支持从1形成 L -。详细的光谱研究1相对于草酸盐和其它阴离子人为了检查选择性，干扰已经完成，结合比，检测（LOD）和其它参数的极限。探针1在生物 pH 值下可检测低至 0.19 μM 的含水草酸根离子。