α-chloroacetophenone semicarbazone | 52376-89-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-chloroacetophenone semicarbazone
• 英文别名: 2-chloro-1-phenyl-ethanone semicarbazone；PhC(NNHC(O)NH2)CH2Cl；2-Chlor-1-phenyl-aethanon-semicarbazon；[(2-Chloro-1-phenylethylidene)amino]urea
• CAS: 52376-89-3
• 化学式: C₉H₁₀ClN₃O
• 分子量: 211.651
• InChiKey: BHQOAOOLEQMTAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  α-chloroacetophenone semicarbazone 在 碳酸氢钠 作用下， 生成 3,6-diphenyl-5,6-dihydro-4H-pyridazine-1-carboxylic acid amide
  参考文献：
  名称：

  Cohen et al., Journal of the American Chemical Society, 1957, vol. 79, p. 4400,4404

  摘要：

  DOI：
• 作为产物：
  描述：

  alpha-氯乙酰苯 生成 α-chloroacetophenone semicarbazone
  参考文献：
  名称：

  Hoogeveen; van Hoogstraten, Recueil des Travaux Chimiques des Pays-Bas, 1933, vol. 52, p. 378,381

  摘要：

  DOI：

文献信息

• Kinetic studies of nucleophilic substitution of various halothiadiazoles with methoxide ion
  作者：B. Modarai、M. H. Ghandehari、H. Massoumi、A. Shafiee、I. Lalezari、A. Badali

  DOI：10.1002/jhet.5570110314

  日期：1974.6

  A number of halo-substituted 1,2,3 and 1,3,4-thiadiozoles have been prepared, their reactivity towards methoxide ion have been studied and the kinetic parameters are reported.

  已经制备了许多卤素取代的1,2,3和1,3,4-噻二唑，已经研究了它们对甲醇离子的反应性并报道了动力学参数。
• Synthesis and 1H nuclear magnetic resonance spectra of some aryl-1,2,3-selenadiazoles
  作者：Alon Caplin

  DOI：10.1039/p19740000030

  日期：——

  A series of aryl-1,2,3-selenadiazoles has been prepared, and their n.m.r. spectral parameters are recorded. The ranges of chemical shifts of the 5-proton due to meta- or para-substitution in the 4-aryl substituent are similar to those for the corresponding protons in the side-chains of substituted benzenes.

  制备了一系列芳基1,2,3-3-硒代二唑，并记录了它们的核磁共振光谱参数。由于4-芳基取代基中的间位或对位取代而引起的5-质子的化学位移范围与取代苯侧链中相应质子的化学位移范围相似。
• Clarke, Simon J.; Gilchrist, Thomas L., Journal of Chemical Research, Miniprint, 1985, # 10, p. 3371 - 3389
  作者：Clarke, Simon J.、Gilchrist, Thomas L.

  DOI：——

  日期：——
• Dinuclear platinum complexes with designer thiolate ligands from the monoalkylation of [Pt2(μ-S)2(PPh3)4]
  作者：Oguejiofo T. Ujam、Sarah M. Devoy、William Henderson、Brian K. Nicholson、T.S. Andy Hor

  DOI：10.1016/j.ica.2010.07.011

  日期：2010.10

  Alkylation reactions of the nucleophilic platinum(II) sulfide complex [Pt-2(mu- S)(2)(PPh3)(4)] with functionalised alkylating agents have been investigated as a versatile synthetic route to dinuclear, cationic sulfide-thiolate complexes of the type [Pt-2(mu-S)(mu-SR)(PPh3)(4)](+), extending the range of thiolate complexes that can be prepared using this methodology. A wide range of functional groups can be incorporated, using appropriate alkylating agents, and include ketone, ester, amide, hydrazone, semicarbazone, thiosemicarbazone, oxime, guanidine, urea and thiourea groups. (C) 2010 Elsevier B.V. All rights reserved.
• Hoogeveen; van Hoogstraten, Recueil des Travaux Chimiques des Pays-Bas, 1933, vol. 52, p. 378,381
  作者：Hoogeveen、van Hoogstraten

  DOI：——

  日期：——