(3,4-dimethoxy-phenyl)-thioacetic acid methylamide | 157370-07-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3,4-dimethoxy-phenyl)-thioacetic acid methylamide
• 英文别名: N-Methyl-C-(3.4-dimethoxy-phenyl)-thioacetamid；(3,4-Dimethoxy-phenyl)-thioessigsaeure-methylamid；2-(3,4-dimethoxyphenyl)-N-methylethanethioamide
• CAS: 157370-07-5
• 化学式: C₁₁H₁₅NO₂S
• 分子量: 225.312
• InChiKey: HEWZQBMJLBDNNP-UHFFFAOYSA-N

物化性质

• 沸点：
  331.6±52.0 °C(Predicted)
• 密度：
  1.123±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3,4-dimethoxy-phenyl)-thioacetic acid methylamide 在 盐酸 作用下， 生成 N-甲基-2-(3,4-二甲氧基苯基)乙胺
  参考文献：
  名称：

  Über neue und über verbesserte Wege zum Aufbau von pharmakologisch wichtigen Aminen V. Über die Synthese von Hydrastinin, Kotarnin und Lodal

  摘要：

  DOI：

  10.1002/ardp.19322700608
• 作为产物：
  描述：

  3,4-二甲氧基苯乙酮 、 alkaline earth salt of/the/ methylsulfuric acid 生成 (3,4-dimethoxy-phenyl)-thioacetic acid methylamide
  参考文献：
  名称：

  Über neue und über verbesserte Wege zum Aufbau von pharmakologisch wichtigen Aminen V. Über die Synthese von Hydrastinin, Kotarnin und Lodal

  摘要：

  DOI：

  10.1002/ardp.19322700608

文献信息

• Leprosy and the anesthesiologist
  作者：Sukanya Mitra、K. K. Gombar

  DOI：10.1007/bf03024874

  日期：2000.10

  Purpose: To discuss particular aspects of leprosy (complications treatment, special population) that have implications for anesthetic management in leprous patients scheduled for surgery.Source: MEDLINE and manual searches of relevant literature. Multiple MEDLINE searches (from 1966 onwards) were done, using LEPROSY as a common Medical Subject Heading (MeSH). Other headings used were: anesthesia, surgery, cardiovascular system, respiratory system, eye, skin, nervous system, genitalia, pathology, psychology and pregnancy. A large number of references were retrieved, but only 18 of them were relevant to our topic. Others were obtained by manual search and cross referencing.Principal findings: Leprosy, especially lepromatous leprosy, is a systemic disease, affecting many organs and systems of the body, e.g., cardiovascular (cardiac dysautonomia), respiratory (impaired cough response, nasal obstruction), hepatobiliary (hepatitis), renal (nephritis), ocular(anesthesia), hematological (reduced red, white and platelet count) and osseous systems (bone resorption).Conclusion: Investigation of the systems likely to be affected by leprosy (e.g., complete hemogram, liver, lung and kidney function tests, Valsalva response, assessment of ocular anesthesia) should form part of a preanesthetic check up in patients with leprosy.