N-(2-hydroxyethyl)-1-benzothiophene-2-carboxamide | 357616-17-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: N-(2-hydroxyethyl)-1-benzothiophene-2-carboxamide
• CAS: 357616-17-2
• 化学式: C₁₁H₁₁NO₂S
• mdl: MFCD08694627
• 分子量: 221.28
• InChiKey: OULLJZIWLLLMDE-UHFFFAOYSA-N

物化性质

• 沸点：
  507.845±30.00 °C(Press: 760.00 Torr)(predicted)
• 密度：
  1.322±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  77.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯并噻吩-2-羧酸 、 C.I.酸性橙108 生成 N-(2-hydroxyethyl)-1-benzothiophene-2-carboxamide
  参考文献：
  名称：

  Preparation and use of ortho-sulfonamido arylhydroxamic acids as matrix metalloproteinase inhibitors

  摘要：

  提供了一种有用的ortho-磺酰胺基芳香羟肟酸，可用于抑制基质金属蛋白酶和治疗与MMP过度表达相关的疾病。

  公开号：

  US06825352B2

文献信息

• Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors
  申请人：Wyeth

  公开号：US06465508B1

  公开（公告）日：2002-10-15

  Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.

  提供了对氨基磺酰基芳基羟肟酸，这些化合物可用于抑制基质金属蛋白酶并治疗与MMP过度表达相关的疾病。
• PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS
  申请人：American Home Products Corporation

  公开号：US20020169184A1

  公开（公告）日：2002-11-14

  Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.

  提供了ortho-磺酰胺基芳香羟肟酸，这些酸在抑制基质金属蛋白酶和治疗与MMP过度表达相关的疾病方面非常有用。
• The preparation and use of ortho-sulfonamido arylhydroxamic acids as matrix metalloproteinase inhibitors
  申请人：Wyeth

  公开号：US20030035332A1

  公开（公告）日：2003-02-20

  Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.

  提供了一种Ortho-磺酰胺基芳香羟肟酸，可用于抑制基质金属蛋白酶和治疗与MMP过度表达相关的病症。
• ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE INHIBITORS
  申请人：Wyeth

  公开号：EP1259488A1

  公开（公告）日：2002-11-27
• US6465508B1
  申请人：——

  公开号：US6465508B1

  公开（公告）日：2002-10-15