3'-Amino-desoxybenzoin | 29955-29-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3'-Amino-desoxybenzoin
• 英文别名: 2-(3-Aminophenyl)-1-phenylethanone
• CAS: 29955-29-1
• 化学式: C₁₄H₁₃NO
• 分子量: 211.263
• InChiKey: YCSOWVIMOQVFHA-UHFFFAOYSA-N

物化性质

• 沸点：
  389.7±17.0 °C(Predicted)
• 密度：
  1.148±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  三氟甲磺酸酐 、 3'-Amino-desoxybenzoin 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 2-[3'-(Trifluoromethanesulfonamido)phenyl]acetophenon
  参考文献：
  名称：

  Antiinflammatory fluoroalkanesulfonanilides. 3. Other fluoroalkanesulfonamido diaryl systems

  摘要：

  A series of isosteres of 3-benzoyltrifluoromethanesulfonanilide involving alternatives to the carbonyl linking group was synthesized and screened for antiinflammatory activity in the carrageenan rat paw edema test. The systems examined were of the type m-CF3SO2NH-C6H4-X-C6H5, where X was -CROH-, -CHR-, -CH(OH)CH2-, -COCH2-, -CH2CO-, greater than C equal to CR2, -CR equal to CH, -C identical to C-, -CH2CH2-, CONH-, -NR-, -O-, -S(O)n- (n equal to 0,1,2), and carbon-carbon single bond. Many ortho and para derivatives were also tested. Several of these new trifluoromethanesulfonanilides proved equipotent with phenylbutazone. The effects on the anticarrageenan activity of both the nature and ring position of X are discussed.

  DOI：

  10.1021/jm00238a013
• 作为产物：
  描述：

  2-(3-nitrophenyl)-1-phenylethan-1-one 在 三氯化铁 、 铁粉 作用下， 生成 3'-Amino-desoxybenzoin
  参考文献：
  名称：

  Linnell; Sharma, Quarterly Journal of Pharmacy and Pharmacology, 1941, vol. 14, p. 259,268

  摘要：

  DOI：

文献信息

• Linnell; Sharma, Quarterly Journal of Pharmacy and Pharmacology, 1941, vol. 14, p. 259,268
  作者：Linnell、Sharma

  DOI：——

  日期：——
• NOUVELLE APPLICATION THERAPEUTIQUE DE DERIVES DU PYRIDYLPYRROLOTHIAZOLE CARBOXAMIDE
  申请人：RHONE-POULENC RORER S.A.

  公开号：EP0628047A1

  公开（公告）日：1994-12-14
• [EN] NOVEL THERAPEUTICAL USE OF PYRIDYLPYRROLOTHIAZOLE CARBOXAMIDE DERIVATIVES
  申请人：RHONE-POULENC RORER S.A.

  公开号：WO1993017027A1

  公开（公告）日：1993-09-02

  (EN) The use of 3-(3-pyridyl) 1H,3H-pyrrolo[1,2-c]thiazole 7-carboxamide derivatives of general formula (I), wherein R is a radical of general formula (II), for which X is an oxygen atom, a carbonyl radical, hydroxymethylene, carboxamido or a -CH2-CO-, _CH=CH-CO- or _CO-CH=CH- radical, and Y is an aromatic heterocyclic or carbocyclic radical, stereoisomeric forms or mixtures thereof, as well as salts thereof, for preparing a drug for the prevention and/or therapy of retroviral infections, is disclosed.(FR) Application de dérivés du (pyridyl-3)-3 1H,3H-pyrrolo[1,2-c]thiazole carboxamide-7 de formule générale (I) dans laquelle R représente un radical de formule générale (II) pour lequel X est un atome d'oxygène, un radical carbonyle, hydroxyméthylène, carboxamido, un radical -CH2-CO-, _CH=CH-CO- ou _CO-CH=CH-, et Y est un radical carbocyclique ou hétérocyclique aromatique, sous leurs formes stéréoisomères ou leurs mélanges ainsi que leurs sels, pour l'obtention d'un médicament destiné à la prophylaxie et/ou au traitement thérapeutique des infections à rétrovirus.
• Antiinflammatory fluoroalkanesulfonanilides. 3. Other fluoroalkanesulfonamido diaryl systems
  作者：G. G. I. Moore、J. K. Harrington、K. F. Swingle

  DOI：10.1021/jm00238a013

  日期：1975.4

  A series of isosteres of 3-benzoyltrifluoromethanesulfonanilide involving alternatives to the carbonyl linking group was synthesized and screened for antiinflammatory activity in the carrageenan rat paw edema test. The systems examined were of the type m-CF3SO2NH-C6H4-X-C6H5, where X was -CROH-, -CHR-, -CH(OH)CH2-, -COCH2-, -CH2CO-, greater than C equal to CR2, -CR equal to CH, -C identical to C-, -CH2CH2-, CONH-, -NR-, -O-, -S(O)n- (n equal to 0,1,2), and carbon-carbon single bond. Many ortho and para derivatives were also tested. Several of these new trifluoromethanesulfonanilides proved equipotent with phenylbutazone. The effects on the anticarrageenan activity of both the nature and ring position of X are discussed.