6-(2-chloro-6-fluorophenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-8-(pyridin-4-yl)pyrimido[4,5-d]pyridazin-5(6H)-one | 1419779-39-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(2-chloro-6-fluorophenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-8-(pyridin-4-yl)pyrimido[4,5-d]pyridazin-5(6H)-one
• 英文别名: 6-(2-Chloro-6-fluorophenyl)-2-[4-(4-methylpiperazin-1-yl)anilino]-8-pyridin-4-ylpyrimido[4,5-d]pyridazin-5-one
• CAS: 1419779-39-7
• 化学式: C₂₈H₂₄ClFN₈O
• 分子量: 543.003
• InChiKey: WQBKODYGABKSAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  39
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  89.8
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] PYRIDAZINO [4, 5 -D] PYRIMIDIN- (6H) -ONE INHIBITORS OF WEE - 1 KINASE<br/>[FR] INHIBITEURS DE KINASE WEE-1 DE TYPE PYRIDAZINO[4,5-D]PYRIMIDIN-(6H)ONE
  申请人：ABBVIE INC

  公开号：WO2013013031A1

  公开（公告）日：2013-01-24

  The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, Formula (I) wherein B, R1, R2, R4, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.

  本发明涉及公式(I)化合物或其药学上可接受的盐，公式(I)中B、R1、R2、R4和m的定义见说明书。本发明还涉及含有上述化合物的组合物，其对抑制wee-1等激酶有用，并且用于治疗癌症等疾病的方法。
• PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES
  申请人：Zhu Gui-Dong

  公开号：US20130023523A1

  公开（公告）日：2013-01-24

  The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein B, R 1 , R 2 , R 4 , and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.

  本发明涉及式(I)的化合物或药物可接受的盐，其中B、R1、R2、R4和m在说明书中有定义。本发明还涉及含有所述化合物的组合物，该组合物对于抑制wee-1等激酶以及治疗癌症等疾病的方法是有用的。
• US8796289B2
  申请人：——

  公开号：US8796289B2

  公开（公告）日：2014-08-05
• US9051327B2
  申请人：——

  公开号：US9051327B2

  公开（公告）日：2015-06-09