细胞色素c3 | 106351-84-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 细胞色素c3
• 中文别名: 1-甲基-4-环己基-1,2,3,6-四氢吡啶
• 英文名称: 1-Methyl-4-cyclohexyl-1,2,3,6-tetrahydropyridine
• 英文别名: 4-cyclohexyl-1-methyl-3,6-dihydro-2H-pyridine
• CAS: 106351-84-2
• 化学式: C₁₂H₂₁N
• 分子量: 179.3
• InChiKey: CQIZBIFTOGBKDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] COMPOUND COMPRISING A MAO TARGETING/ SEEKER MOIETY FOR TREATING HUMAN GLIOMAS<br/>[FR] COMPOSÉ COMPRENANT UN FRAGMENT DE CIBLAGE/RECHERCHE DE MAO POUR LE TRAITEMENT DE GLIOMES HUMAINS
  申请人：METHODIST HOSPITAL RES INST

  公开号：WO2013151584A1

  公开（公告）日：2013-10-10

  Disclosed are compound for targeting chemotherapeutic agents to mammalian mitochondria. Also disclosed are monoamine oxidase compositions, and methods of using them for the selective therapy of mammalian cancers, and in particular, in the treatment of human gliomas. Also disclosed are methods employing the novel targeted chemotherapeutics with one or more conventional anti-cancer therapies, including, for example, radiotherapy.

  本发明涉及用于靶向化学治疗药物到哺乳动物线粒体的化合物。还揭示了单胺氧化酶组成物，并使用它们进行哺乳动物癌症的选择性治疗，特别是在人类胶质瘤的治疗中。还揭示了使用新型靶向化疗药物与一种或多种传统抗癌疗法（例如放疗）的方法。
• Chemotherapeutic Compositions and Methods for Treating Human Gliomas
  申请人：The Methodist Hospital Research Institute

  公开号：US20140323513A1

  公开（公告）日：2014-10-30

  Disclosed are compound for targeting chemotherapeutic agents to mammalian mitochondria. Also disclosed are monoamine oxidase-specific compositions, and methods of using them for the selective therapy of mammalian cancers, and in particular, in the treatment of human gliomas. Also disclosed are methods employing the novel targeted chemotherapeutics with one or more conventional anti-cancer therapies, including, for example, radiotherapy, or multi-drug regimens.

  本发明涉及用于靶向化疗药物作用于哺乳动物线粒体的化合物。还公开了单胺氧化酶特异性组合物，以及使用它们进行哺乳动物癌症的选择性治疗的方法，特别是在人类胶质瘤的治疗中。还公开了使用新型靶向化疗药物与一种或多种常规抗癌疗法，包括放射治疗或多药物方案的方法。
• COMPOUND COMPRISING A MAO TARGETING/SEEKER MOIETY FOR TREATING HUMAN GLIOMAS
  申请人：The Methodist Hospital Research Institute

  公开号：EP3815685A2

  公开（公告）日：2021-05-05

  Disclosed are compound for targeting chemotherapeutic agents to mammalian mitochondria. Also disclosed are monoamine oxidase compositions, and methods of using them for the selective therapy of mammalian cancers, and in particular, in the treatment of human gliomas. Also disclosed are methods employing the novel targeted chemotherapeutics with one or more conventional anti-cancer therapies, including, for example, radiotherapy.

  本发明公开了将化疗药物靶向哺乳动物线粒体的化合物。还公开了单胺氧化酶组合物，以及使用它们选择性治疗哺乳动物癌症，特别是治疗人类胶质瘤的方法。还公开了将新型靶向化疗药物与一种或多种常规抗癌疗法（包括放疗等）结合使用的方法。
• Chemotherapeutic compositions and methods for treating human gliomas
  申请人：The Methodist Hospital

  公开号：US10555936B2

  公开（公告）日：2020-02-11

  Disclosed are compound for targeting chemotherapeutic agents to mammalian mitochondria. Also disclosed are monoamine oxidase-specific compositions, and methods of using them for the selective therapy of mammalian cancers, and in particular, in the treatment of human gliomas. Also disclosed are methods employing the novel targeted chemotherapeutics with one or more conventional anti-cancer therapies, including, for example, radiotherapy, or multi-drug regimens.

  所公开的是将化疗药物靶向哺乳动物线粒体的化合物。还公开了单胺氧化酶特异性组合物，以及用它们选择性治疗哺乳动物癌症，特别是治疗人类胶质瘤的方法。还公开了将新型靶向化疗药物与一种或多种常规抗癌疗法（包括放疗等）或多种药物疗法结合使用的方法。
• COMPOUND COMPRISING A MAO TARGETING/ SEEKER MOIETY FOR TREATING HUMAN GLIOMAS
  申请人：The Methodist Hospital Research Institute

  公开号：EP2804604A1

  公开（公告）日：2014-11-26