(2-Oxo-4-phenyl-butyl)-phosphonic acid | 51008-95-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Oxo-4-phenyl-butyl)-phosphonic acid
• 英文别名: (2-Oxo-4-phenylbutyl)phosphonic acid
• CAS: 51008-95-8
• 化学式: C₁₀H₁₃O₄P
• 分子量: 228.185
• InChiKey: SGPMRFZESVKHSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Process for the preparation of latanoprost
  申请人：——

  公开号：US20030149294A1

  公开（公告）日：2003-08-07

  Disclosed is a novel process for the preparation of the anti-glaucoma drug Latanoprost, in good yield, in large amounts and with desired purity. Also disclosed are novel intermediates for the above process.

  揭示了一种新颖的制备抗青光眼药物拉唑前列素的方法，产量高，数量大且纯度良好。还披露了上述方法的新颖中间体。
• Method for preparing prostaglandin derivative
  申请人：Daiichi Fine Chemical Co., Ltd.

  公开号：EP1886992A1

  公开（公告）日：2008-02-13

  A method for preparing a prostaglandin derivative represented by the following general formula (I): (wherein Ph represents phenyl group, R1 represents a C1-7 alkyl group, a C1-7 alkenyl group, phenyl group, or benzyl group), which comprises the successive steps (1) to (8) described in the specification, or any one step or two or more successive steps selected from the group consisting of the steps (1) to (8). A method for efficiently, inexpensively and safely preparing prostaglandin derivatives, of which typical example is latanoprost, is provided.

  一种用以下一般式(I)代表的前列腺素衍生物的制备方法：（其中Ph代表苯基，R1代表C1-7烷基，C1-7烯基，苯基或苄基），其中包括在说明书中描述的连续步骤（1）至（8），或者从步骤（1）至（8）组成的步骤中选择的一个步骤，或者选择两个或更多连续步骤。提供了一种高效、廉价和安全地制备前列腺素衍生物的方法，其中典型示例是拉唑前列酮。
• METHOD FOR PREPARING PROSTAGLANDIN DERIVATIVE
  申请人：MURATA Noriaki

  公开号：US20080033176A1

  公开（公告）日：2008-02-07

  A method for preparing a prostaglandin derivative represented by the following general formula (I): (wherein Ph represents phenyl group, R 1 represents a C 1-7 alkyl group, a C 1-7 alkenyl group, phenyl group, or benzyl group), which comprises the successive steps (1) to (8) described in the specification, or any one step or two or more successive steps selected from the group consisting of the steps (1) to (8). A method for efficiently, inexpensively and safely preparing prostaglandin derivatives, of which typical example is latanoprost, is provided.

  一种用以下一般式(I)表示的前列腺素衍生物的制备方法：（其中Ph代表苯基，R1代表C1-7烷基，C1-7烯基，苯基或苄基），该方法包括规范中描述的连续步骤（1）至（8），或者从步骤（1）至（8）中选择的任一步骤或两个或更多连续步骤。提供了一种高效、廉价和安全制备前列腺素衍生物的方法，其中典型示例是拉唑前列醇。
• BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES
  申请人：Maruyama Toru

  公开号：US20130310438A1

  公开（公告）日：2013-11-21

  Provided is a compound which has strong intraocular pressure lowering action and has no side effect on eyes such as ocular stimulating property, humor protein rise etc. Since a compound represented by the formula (I): (wherein definition of each group is as described in the specification), or a salt thereof, a solvate thereof, or a prodrug thereof has strong intraocular pressure lowering activity and, further, has no side effect on eyes such as ocular stimulating property (hyperemia, corneal clouding etc.), aqueous humor protein rise etc., it has high safety, and can be an excellent agent for preventing and/or treating glaucoma etc.

  提供的是一种化合物，具有强烈的降低眼内压力的作用，并且对眼睛没有刺激性、湿润蛋白升高等副作用。由公式（I）所表示的化合物（其中每个基团的定义如规范中所述），或其盐、溶剂合物或前药具有强烈的降低眼内压力的活性，并且没有眼睛刺激性（充血、角膜混浊等）、房水蛋白升高等副作用，具有高安全性，可以成为预防和/或治疗青光眼等疾病的优秀药物。
• NOVEL PROCESS FOR THE PREPARATION OF PROSTAGLANDINS AND INTERMEDIATES THEREOF
  申请人：Aswathanarayanappa Chandrashekar

  公开号：US20120209011A1

  公开（公告）日：2012-08-16

  This invention relates to novel process for the preparation of prostaglandin compounds having formula (K), wherein R is selected from the group consisting of C 1 -C 7 alkyl; C 7 -C 17 aralkyl wherein the aryl group is unsubstituted or substituted with one to three substituents selected from the group consisting of C 1 -C 6 alkyl, halo and CF 3 ; and (CH 2 ) n OR 2 wherein n is from 1 to 3 and R 2 represents a C 6 -C 10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C 1 -C 6 alkyl, halo and CF 3 ; and R 1 is selected from OR 3 and NHR 3 wherein R 3 is C 1 -C 6 alkyl, H; and dashed lines represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.

  本发明涉及一种新型的制备具有式（K）的前列腺素化合物的方法，其中R选自以下组中的一种：C1-C7烷基；C7-C17芳基烷基，其中芳基基团未取代或取代有1至3个取代基，所述取代基选自C1-C6烷基，卤素和CF3；以及（CH2）nOR2，其中n为1至3，R2代表未取代或取代有1至3个取代基的C6-C10芳基基团，所述取代基选自C1-C6烷基，卤素和 ；R1选自OR3和NHR3，其中R3为C1-C6烷基，H；虚线表示双键或单键。本发明还公开了新型中间体。