1,6,9,14-tetraazacyclohexadecane | 70072-64-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,6,9,14-tetraazacyclohexadecane
• 英文别名: 1,4,9,12-tetrazacyclohexadecane
• CAS: 70072-64-9
• 化学式: C₁₂H₂₈N₄
• 分子量: 228.381
• InChiKey: XDCDILPJAMBPKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.08
• 重原子数：
  16.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  48.12
• 氢给体数：
  4.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  copper(II) nitrate trihydrate 、 1,6,9,14-tetraazacyclohexadecane 以 甲醇 为溶剂， 以35%的产率得到(1,6,9,14-tetraazacyclohexadecane) copper(II) nitrate
  参考文献：
  名称：

  Shakir, Mohammad; Varkey, Saji P., Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1995, vol. 34, # 5, p. 355 - 359

  摘要：

  DOI：
• 作为产物：
  描述：

  2,5,10,13-tetraoxo-1,6,9,14-tetraazacyclohexadecane 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 56.0h， 以22%的产率得到1,6,9,14-tetraazacyclohexadecane
  参考文献：
  名称：

  Shakir, Mohammad; Varkey, Saji P.; Nasman, Omar S. M., Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1996, vol. 35, # 8, p. 671 - 676

  摘要：

  DOI：

文献信息

• Studies on Biologically Potent Tetraazamacrocyclic Complexes of Bivalent Tin
  作者：Ashu Chaudhary、R. V. Singh

  DOI：10.1080/10426500307932

  日期：2003.3.1

  Fourteen- to eighteen-membered tetraamide macrocyclic ligands N4L1-N4L4 have been prepared by the condensation of 1,2-diaminoethane or 1,3-diaminopropane with malonic or succinic acid in the presence of condensing reagents dicyclohexylcarbodiimide and 4-dimethylaminopyridine. On reduction, these macrocyclic ligands give a new series of tetraazamacrocycles MacL(1)-MacL(4) which form complexes with tin(II) chloride. The ligands and their complexes were characterized by elemental analyses, molecular weight determinations, infrared and H-1 NMR spectral studies. The hexacoordinated state for tin has been confirmed by spectral studies. An octahedral geometry for these complexes has been proposed as the binding sites are the nitrogen atoms of the macrocycles. On the basis of the chemical composition the representation of the complexes as [Sn(MacL(n))Cl-2] (n = 1-4) has been established. The ligands and their complexes also have been screened for their antifungal and antibacterial activities and the findings have been reported and explained.