5-benzo[1,3]dioxol-5-yl-6-(6-methyl-pyridin-2-yl)-2,3-dihydro-1H-imidazolo[1,2-a]imidazole | 1418305-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 5-benzo[1,3]dioxol-5-yl-6-(6-methyl-pyridin-2-yl)-2,3-dihydro-1H-imidazolo[1,2-a]imidazole
• 英文别名: 5-benzo[1,3]dioxol-5-yl-6-(6-methyl-pyridine-2-yl)-2,3-dihydro-1H-imidazo[1,2-a]imidazole；5-benzo[1,3]dioxol-5-yl-6-(6-methyl-pyridin-2-yl)-2,3-dihydro-1H-imidazo[1,2-a]imidazole；5-Benzo[1,3]dioxol-5-yl-6-(6-methylpyridin-2-yl)-2,3-dihydro-1H-imidazo[1,2-a]-imidazol；5-(1,3-benzodioxol-5-yl)-6-(6-methylpyridin-2-yl)-2,3-dihydro-1H-imidazo[1,2-a]imidazole
• CAS: 1418305-60-8
• 化学式: C₁₈H₁₆N₄O₂
• 分子量: 320.351
• InChiKey: KFZWSKRSBVNDBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS
  申请人：LEE Ju Young

  公开号：US20130018052A1

  公开（公告）日：2013-01-17

  The present invention provides a novel 2-pyridyl substituted imidazole derivative, or a pharmaceutically acceptable salt or solvate thereof, which selectively inhibits the transforming growth factor-β (TGF-β) type I receptor (ALK5) and/or the activin type I receptor (ALK4); a pharmaceutical composition comprising same as an active ingredient; and a use of the 2-pyridyl substituted imidazole derivative for the manufacture of a medicament for preventing or treating a disease mediated by ALK5 and/or ALK4 receptors in a mammal.

  本发明提供了一种新型的2-吡啶基取代咪唑衍生物，或其药学上可接受的盐或溶剂，该衍生物选择性地抑制转化生长因子-β（TGF-β）类型I受体（ALK5）和/或活化素类型I受体（ALK4）；一种包含其作为活性成分的制药组合物；以及使用该2-吡啶基取代咪唑衍生物制造哺乳动物ALK5和/或ALK4受体介导的疾病的药物的用途。
• [EN] 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS<br/>[FR] 2-PYRIDYLIMIDAZOLES SUBSTITUÉS UTILISÉS COMME INHIBITEURS D'ALK5 ET/OU D'ALK4
  申请人：SK CHEMICALS CO LTD

  公开号：WO2013009140A2

  公开（公告）日：2013-01-17

  The present invention provides a novel 2-pyridyl substituted imidazole derivative, or a pharmaceutically acceptable salt or solvate thereof, which selectively inhibits the transforming growth factor-β (TGF-β) type I receptor (ALK5) and/or the activin type I receptor (ALK4); a pharmaceutical composition comprising same as an active ingredient; and a use of the 2-pyridyl substituted imidazole derivative for the manufacture of a medicament for preventing or treating a disease mediated by ALK5 and/or ALK4 receptors in a mammal.