2,2'-[(3,4-diaminophenyl)imino]bis[ethanol] | 117043-69-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,2'-[(3,4-diaminophenyl)imino]bis[ethanol]
• 英文别名: 2-[3,4-diamino-N-(2-hydroxyethyl)anilino]ethanol
• CAS: 117043-69-3
• 化学式: C₁₀H₁₇N₃O₂
• 分子量: 211.264
• InChiKey: ZARFDWCFIFQKHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  95.7
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(4-[imino(ethoxy)methyl]phenoxymethyl)-1,2-dicarba-closo-dodecaborane(12) hydrochloride 、 2,2'-[(3,4-diaminophenyl)imino]bis[ethanol] 以 异丙醇 为溶剂， 以33%的产率得到2,2'-((2-(4-[1,2-dicarba-closo-dodecaboran(12)-2-ylmethoxy]phenyl)-1H-benzimidazol-5-yl)imino)bis[ethanol]
  参考文献：
  名称：

  Labelling of Carbaboranyl Compounds with a Selenium Atom with a View to Applications in Boron-Neutron-Capture Therapy (BNCT) and Positron-Emission Tomography (PET)

  摘要：

  We synthesized 2'-carbaboranyl-2,5'-bi-1H-benzimidazoles containing 10 B-atoms and labeled with Se or the positron-emitting radionuclide Se-73 (t(1/2) = 7.1 h), with a view to their application to cancel. treatment by boron-neutron-capture therapy (BNCT) and to compound-distribution measurements in vivo by positron-emission tomography (PET). Thus, 2,2'-{[2'-(4-[1,2-dicarba-closo-dodecaboran(12)-2-ylmethoxy]phenyl]-[2,5'-bi-1H-benzimidazol]-5-yl}imino)bis[ethanol] (26c) was obtained by the reaction of 2,2'-[(3,4-diaminephenyl)imino]bis[ethanol] (19) with ethyl 2-{4-[1,2-dicarba-closo-dodecaboran(12)-2-ylmethoxy]phenyl}-1H-benzimidazole-5-carboximidate hydrochloride (25), as well as the analogues 26a and 26b (Scheme 6). Tosylation of compound 26c gave 4 regioisomers 27a-d, which, after selenation, produced 2'-{4-[1,2-dicarba-closo-dodecaboran(12)-2-ylmethoxy]phenyl}-5-(tetrahydro-2H-1,4-selenazin-4-yl)-2,5'-bi-1H-benzimidazole (29) in 42% yield (Scheme 7).

  DOI：

  10.1002/1522-2675(20001108)83:11<2926::aid-hlca2926>3.0.co;2-6
• 作为产物：
  描述：

  N-(4-氨基-3-硝基苯基)二乙醇胺 在 Ru-carbon 一水合肼 作用下， 以 乙醇 为溶剂， 反应 1.5h， 以90%的产率得到2,2'-[(3,4-diaminophenyl)imino]bis[ethanol]
  参考文献：
  名称：

  Labelling of Carbaboranyl Compounds with a Selenium Atom with a View to Applications in Boron-Neutron-Capture Therapy (BNCT) and Positron-Emission Tomography (PET)

  摘要：

  We synthesized 2'-carbaboranyl-2,5'-bi-1H-benzimidazoles containing 10 B-atoms and labeled with Se or the positron-emitting radionuclide Se-73 (t(1/2) = 7.1 h), with a view to their application to cancel. treatment by boron-neutron-capture therapy (BNCT) and to compound-distribution measurements in vivo by positron-emission tomography (PET). Thus, 2,2'-{[2'-(4-[1,2-dicarba-closo-dodecaboran(12)-2-ylmethoxy]phenyl]-[2,5'-bi-1H-benzimidazol]-5-yl}imino)bis[ethanol] (26c) was obtained by the reaction of 2,2'-[(3,4-diaminephenyl)imino]bis[ethanol] (19) with ethyl 2-{4-[1,2-dicarba-closo-dodecaboran(12)-2-ylmethoxy]phenyl}-1H-benzimidazole-5-carboximidate hydrochloride (25), as well as the analogues 26a and 26b (Scheme 6). Tosylation of compound 26c gave 4 regioisomers 27a-d, which, after selenation, produced 2'-{4-[1,2-dicarba-closo-dodecaboran(12)-2-ylmethoxy]phenyl}-5-(tetrahydro-2H-1,4-selenazin-4-yl)-2,5'-bi-1H-benzimidazole (29) in 42% yield (Scheme 7).

  DOI：

  10.1002/1522-2675(20001108)83:11<2926::aid-hlca2926>3.0.co;2-6

文献信息

• [EN] PROCESS FOR DYEING KERATIN FIBRES USING COLOURED OLIGOMERS AND/OR POLYMERS DERIVED FROM SELF-OXIDIZING COMPOUNDS, COMPOSITION AND COLOURING AGENT FOR THE SAME<br/>[FR] PROCÉDÉ DE COLORATION DE FIBRES DE KÉRATINE AU MOYEN D'OLIGOMÈRES ET/OU DE POLYMÈRES COLORÉS DÉRIVÉS DE COMPOSÉS AUTO-OXYDANTS, COMPOSITION ET AGENT COLORANT POUR CELUI-CI
  申请人：OREAL

  公开号：WO2015086675A1

  公开（公告）日：2015-06-18

  The invention relates to a) a process for dyeing keratin materials using a colouring agent chosen from coloured oligomers and polymers obtained from the polycondensation of i) self-oxidizing compounds in the presence of ii) one or more ingredients chosen from radical initiators and/or chemical oxidizing agents, b) a composition comprising one or more coloured oligomers and/or one or more coloured polymers as defined previously and c) a coloured oligomeric or polymeric colouring agent obtained by reaction between i) and ii) as defined previously, and to the use of the coloured oligomer(s) or polymer(s) for dyeing keratin materials. The dyeing process and the composition according to the invention especially afford a long-lasting colouring on keratin fibres, which is strong, chromatic and/or homogeneous.