N,N-diphenyl-4-phenylmethoxyaniline | 769162-54-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-diphenyl-4-phenylmethoxyaniline
• CAS: 769162-54-1
• 化学式: C₂₅H₂₁NO
• 分子量: 351.448
• InChiKey: PXKIVCMENSRAIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(benzyloxy)phenyl dimethylsulfamate 、 bromomagnesium diphenylamide 在 bis(1,5-cyclooctadiene)nickel (0) 、 1,3-双(2,6-二异丙基苯基)咪唑-2-烯 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 24.0h， 以10%的产率得到N,N-diphenyl-4-phenylmethoxyaniline
  参考文献：
  名称：

  Ni-catalyzed arylation of bromomagnesium diarylamides with aryl N,N-dimethylsulfamates

  摘要：

  The combination use of Ni(cod)(2) and N,N-1,3-bis(2,6-diisopropylphenyl)-4-imidazoline-2-ylidene as a catalyst successfully gave unsymmetrical N,N-diaryl-N',N'-diphenyl-1,1'-biphenyl-4,4'-diamines through the arylation of bromomagnesium diarylamide with 1-(4'-diphenylamino-1,1'-biphenylyl) N,N-dimethylsulfamate. This Ni catalyst and Grignard reagents of diaryl or monoarylamides were also useful in the syntheses of various triarylamines and diarylamines from corresponding aryl N,N-dimethylsulfamates. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.08.015

文献信息

• Ni-catalyzed arylation of bromomagnesium diarylamides with aryl N,N-dimethylsulfamates
  作者：Hiroshi Tadaoka、Tetsu Yamakawa

  DOI：10.1016/j.tetlet.2012.08.015

  日期：2012.10

  The combination use of Ni(cod)(2) and N,N-1,3-bis(2,6-diisopropylphenyl)-4-imidazoline-2-ylidene as a catalyst successfully gave unsymmetrical N,N-diaryl-N',N'-diphenyl-1,1'-biphenyl-4,4'-diamines through the arylation of bromomagnesium diarylamide with 1-(4'-diphenylamino-1,1'-biphenylyl) N,N-dimethylsulfamate. This Ni catalyst and Grignard reagents of diaryl or monoarylamides were also useful in the syntheses of various triarylamines and diarylamines from corresponding aryl N,N-dimethylsulfamates. (C) 2012 Elsevier Ltd. All rights reserved.