5-Oxo-1-(2,2,2-trifluoroethyl)pyrrolidine-3-carboxylic acid | 1016823-41-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 5-Oxo-1-(2,2,2-trifluoroethyl)pyrrolidine-3-carboxylic acid
• CAS: 1016823-41-8
• 化学式: C₇H₈F₃NO₃
• mdl: MFCD09944063
• 分子量: 211.14
• InChiKey: PWWZFHSEJSRPFA-UHFFFAOYSA-N

物化性质

• 沸点：
  333.9±42.0 °C(Predicted)
• 密度：
  1.481±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1761542A2

  公开（公告）日：2007-03-14
• [EN] HETEROCYCLIC ANTIVIRAL COMPOUNDS<br/>[FR] COMPOSES ANTIVIRAUX HETEROCYCLIQUES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2005121145A2

  公开（公告）日：2005-12-22

  Chemokine receptor antagonists, in particular, 3,7-diazabicyclo [3.3.0] octane compounds according to formula (I) are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are allieviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula (I).