6-(2-fluorophenyl)-2-(3-azabicyclo[3.3.0]oct-3-yl-amino)-8-(4-fluorobenzyl)-pyrido[2,3-d]pyrimidin-7(8H)-one | 905285-62-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(2-fluorophenyl)-2-(3-azabicyclo[3.3.0]oct-3-yl-amino)-8-(4-fluorobenzyl)-pyrido[2,3-d]pyrimidin-7(8H)-one
• 英文别名: 2-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-ylamino)-6-(2-fluorophenyl)-8-[(4-fluorophenyl)methyl]pyrido[2,3-d]pyrimidin-7-one
• CAS: 905285-62-3
• 化学式: C₂₇H₂₅F₂N₅O
• 分子量: 473.525
• InChiKey: ITKBZSRVQYHARV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  61.4
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• AZABICYCLO DERIVATIVES AS ANTI-INFLAMMATORY AGENTS
  申请人：Palle Venkata P.

  公开号：US20090036472A1

  公开（公告）日：2009-02-05

  The present invention relates to novel azabicyclo derivatives of Formula (I) as anti-inflammatory agents which are useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis.

  本发明涉及一种新型的Formula (I)的氮杂双环衍生物，作为抗炎药物，可用于抑制和预防炎症及相关病理，包括脓毒症、类风湿关节炎、炎症性肠病、1型糖尿病、哮喘、慢性阻塞性肺病、器官移植排斥反应和牛皮癣。
• [EN] AZABICYCLO DERIVATIVES AS ANTI-INFLAMMATORY AGENTS<br/>[FR] DERIVES AZABICYCLO UTILISES COMME AGENTS ANTI-INFLAMMATOIRES
  申请人：RANBAXY LAB LTD

  公开号：WO2006082492A1

  公开（公告）日：2006-08-10

  [EN] The present invention relates to novel azabicyclo derivatives of Formula (I) as anti-inflammatory agents which are useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis.
  [FR] La présente invention concerne de nouveaux dérivés azabicyclo de formule (I) qui sont utilisés comme agents anti-inflammatoires pour inhiber et prévenir des inflammations et des pathologies associées, notamment des maladies inflammatoires et auto-immunes, telles que la sepsie, la polyarthrite rhumatoïde, les maladies intestinales inflammatoires, le diabète de type 1, l'asthme, les maladies pulmonaires obstructives chroniques, le rejet d'une greffe d'organe et le psoriasis.