3-Bromo-4-[(4-chlorophenyl)amino]furan-2(5H)-one | 1310679-28-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Bromo-4-[(4-chlorophenyl)amino]furan-2(5H)-one
• 英文别名: 4-bromo-3-(4-chloroanilino)-2H-furan-5-one
• CAS: 1310679-28-7
• 化学式: C₁₀H₇BrClNO₂
• 分子量: 288.528
• InChiKey: SOPQQXVIYGTYMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,4-二溴呋喃-2(5H)-酮 、 对氯苯胺 在 碳酸氢钠 作用下， 以 甲醇 为溶剂， 反应 44.0h， 以87%的产率得到3-Bromo-4-[(4-chlorophenyl)amino]furan-2(5H)-one
  参考文献：
  名称：

  Synthesis of 3-bromotetronamides via amination of 3,4-dibromofuran-2(5H)-one

  摘要：

  This work describes the direct synthesis of 3-bromotetronamides in good yields through the reaction of 3,4-dibromofuran-2(5H)-one, obtained from furfural, with primary and secondary amines. Aromatic amines were more tolerated than aliphatic and heteroaromatic ones. The X-ray structures of five derivatives are described.

  DOI：

  10.1590/s0103-50532011000300026

文献信息

• Synthesis of 3-bromotetronamides via amination of 3,4-dibromofuran-2(5H)-one
  作者：Silvio Cunha、Caio C Oliveira、José R Sabino

  DOI：10.1590/s0103-50532011000300026

  日期：——

  This work describes the direct synthesis of 3-bromotetronamides in good yields through the reaction of 3,4-dibromofuran-2(5H)-one, obtained from furfural, with primary and secondary amines. Aromatic amines were more tolerated than aliphatic and heteroaromatic ones. The X-ray structures of five derivatives are described.