5-chloro-2-cyclohexylisoindoline-1,3-dione | 5566-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 5-chloro-2-cyclohexylisoindoline-1,3-dione
• 英文别名: 5-chloro-2-cyclohexyl-isoindole-1,3-dione；5-Chloro-2-cyclohexylisoindole-1,3-dione
• CAS: 5566-68-7
• 化学式: C₁₄H₁₄ClNO₂
• 分子量: 263.724
• InChiKey: KVJYREOQXREEPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环己基异氰酸酯 、 4-氯-2-碘苯甲酸甲酯 在 dibromo[1,2-bis(diphenylphosphino)ethane]nickel(II) 三乙胺 、 1,2-双(二苯基膦)乙烷 、 锌 作用下， 以 乙腈 为溶剂， 反应 36.0h， 以51%的产率得到5-chloro-2-cyclohexylisoindoline-1,3-dione
  参考文献：
  名称：

  Nickel-catalyzed coupling of isocyanates with 1,3-iodoesters and halobenzenes: a novel method for the synthesis of imide and amide derivatives

  摘要：

  通过异氰酸酯与邻碘苯甲酸酯和卤代芳烃的反应，采用NiBr2(dppe)/dppe/Zn体系催化，便捷地合成了取代的酰亚胺和酰胺衍生物，产率中等至良好，并且对功能团具有极好的耐受性。

  DOI：

  10.1039/b506903c

文献信息

• Phosphazenium salt phase transfer catalysts
  申请人：Brunelle Joseph Daniel

  公开号：US20060069291A1

  公开（公告）日：2006-03-30

  A method for carrying out a chemical reaction between at least two reactants occupying separate phases within a multiphase reaction mixture has been discovered in which at least one phosphazenium salt is employed as a phase transfer catalyst. The remarkable utility of phosphazenium salts as phase transfer catalysts is illustrated by the preparation of aromatic ethers. The phosphazenium salt phase transfer catalysts are shown to be especially useful in the preparation of aromatic polyethers such as polyether sulfones.

  已经发现了一种在多相反应混合物中进行至少两种占据不同相位的反应物之间的化学反应的方法，其中至少一种磷氮盐被用作相转移催化剂。磷氮盐作为相转移催化剂的显著实用性可通过芳香醚的制备来说明。磷氮盐相转移催化剂在芳香聚醚如聚醚砜的制备中被证明特别有用。
• Phoshazenium salt phase transfer catalysts
  申请人：Brunelle Joseph Daniel

  公开号：US20070112223A1

  公开（公告）日：2007-05-17

  A method for carrying out a chemical reaction between at least two reactants occupying separate phases within a multiphase reaction mixture has been discovered in which at least one phosphazenium salt is employed as a phase transfer catalyst. The remarkable utility of phosphazenium salts as phase transfer catalysts is illustrated by the preparation of aromatic ethers. The phosphazenium salt phase transfer catalysts are shown to be especially useful in the preparation of aromatic polyethers such as polyether sulfones.

  一种用于在多相反应混合物中进行至少两种占据不同相的反应物之间的化学反应的方法已被发现，其中至少使用一种磷氮盐作为相转移催化剂。磷氮盐作为相转移催化剂的显著实用性通过芳香醚的制备得到了说明。磷氮盐相转移催化剂在芳香族聚醚的制备中尤其有用，例如聚醚砜的制备。
• POLYTHIOETHERIMIDES AND METHOD FOR PRODUCING THEREOF
  申请人：Ningbo Institute Of Materials Technology And Engineering, Chinese Academy Of Sciences

  公开号：EP2233512B1

  公开（公告）日：2013-03-20
• METHOD OF MAKING AN AROMATIC POLYETHER COMPOSITION USING PHOSPHAZENIUM SALT PHASE TRANSFER CATALYSTS
  申请人：BRUNELLE DANIEL JOSEPH

  公开号：US20100204431A1

  公开（公告）日：2010-08-12

  A method for carrying out a chemical reaction between at least two reactants occupying separate phases within a multiphase reaction mixture has been discovered in which at least one phosphazenium salt is employed as a phase transfer catalyst. The remarkable utility of phosphazenium salts as phase transfer catalysts is illustrated by the preparation of aromatic ethers. The phosphazenium salt phase transfer catalysts are shown to be especially useful in the preparation of aromatic polyethers such as polyether sulfones.
• US7705190B2
  申请人：——

  公开号：US7705190B2

  公开（公告）日：2010-04-27