4-phenylbutyl ethyl ether | 27364-31-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-phenylbutyl ethyl ether
• 英文别名: ethyl-(4-phenyl-butyl)-ether；4-Aethoxy-1-phenyl-butan；Aethyl-(4-phenyl-butyl)-aether；4-Ethoxybutylbenzene
• CAS: 27364-31-4
• 化学式: C₁₂H₁₈O
• 分子量: 178.274
• InChiKey: IBQMEVKHCHLZMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-苯丁酸乙酯 在 三乙基硅烷 、 三氟甲磺酸三甲基硅酯 、 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 以78%的产率得到4-phenylbutyl ethyl ether
  参考文献：
  名称：

  Reduction of carboxylic esters to ethers with triethyl silane in the combined use of titanium tetrachloride and trimethylsilyl trifluoromethanesulfonate

  摘要：

  Aliphatic acyclic and cyclic ethers are prepared on treatment of their corresponding carboxylic esters and lactones with triethylsilane in the presence of titanium tetrachloride and trimethylsilyl trifluoromethanesulfonate. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00420-3

文献信息

• [EN] MTORC MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE MTORC ET LEURS UTILISATIONS
  申请人：AEOVIAN PHARMACEUTICALS INC

  公开号：WO2020154447A1

  公开（公告）日：2020-07-30

  Novel rapamycin analogs and uses thereof are disclosed herein. The rapamycin analogs of the present disclosure show increased mTORC1 specificity and lowered mTORC2 specificity relative to rapamycin.

  本文披露了新型雷帕霉素类似物及其用途。本公开的雷帕霉素类似物相对于雷帕霉素表现出增加的mTORC1特异性和降低的mTORC2特异性。
• Ramart-Lucas; Hoch, Annales de Chimie (Cachan, France), 1932, vol. <10> 17, p. 207,244
  作者：Ramart-Lucas、Hoch

  DOI：——

  日期：——
• NOVEL PROCESS
  申请人：Gore Vinayak G.

  公开号：US20080262267A1

  公开（公告）日：2008-10-23

  The present invention relates to processes for the preparation of 4-hydroxy-α′-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthoate (salmeterol xinafoate) (12a), the preparation of 4-hydroxy-α′-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (salmeterol) (11), the preparation of protected N-[6-(4-phenylbutoxy)hexyl]amine intermediates (7), and the preparation of 6-substituted (4-phenylbutoxy)hexane intermediates (5), shown below, wherein X is a leaving group and Pg is a protecting group.
• INK, INK CARTRIDGE, INK JET RECORDING DEVICE, INK JET INK PRINTED MATTER, COMPOUND, AND COMPOSITION
  申请人：MORITA Mitsunobu

  公开号：US20140363634A1

  公开（公告）日：2014-12-11

  Ink contains at least one of a compound represented by the following chemical formula 1, a compound represented by chemical formula 2, a compound represented by chemical formula 3, or a compound represented by chemical formula 4.
• INK, INK CARTRIDGE, INK JET RECORDING DEVICE, INK JET INK PRINTED MATTER, COMPOUND, AND COMPOSITION
  申请人：MORITA Mitsunobu

  公开号：US20170137644A1

  公开（公告）日：2017-05-18

  Ink contains at least one of a compound represented by the following chemical formula 1, a compound represented by chemical formula 2, a compound represented by chemical formula 3, or a compound represented by chemical formula 4.