(S)-5-((3-fluorophenyl)ethynyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide | 2127107-15-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-5-((3-fluorophenyl)ethynyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide
• 英文别名: Phi-101；3-(carbamoylamino)-5-[2-(3-fluorophenyl)ethynyl]-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide
• CAS: 2127107-15-5
• 化学式: C₁₉H₁₉FN₄O₂S
• 分子量: 386.45
• InChiKey: ULVAGWVTXBTFRN-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• USE OF 2,3,5-SUBSTITUTED THIOPHENE COMPOUND TO PREVENT, AMELIORATE, OR TREAT BREAST CANCERS
  申请人：Pharos Ibio Co., Ltd.

  公开号：EP3804718A1

  公开（公告）日：2021-04-14

  A composition for preventing, ameliorating or treating breast cancer, the composition containing a 2,3,5-substituted thiophene compound according to one embodiment of the present disclosure has an excellent activity of inhibiting the proliferation of breast cancers, particularly triple-negative breast cancer and Herceptin-resistant breast cancer, which have high mortality because there has yet been no effective therapeutic method therefor. Thus, the composition may be advantageously used for the prevention, amelioration or treatment of breast cancer.

  一种用于预防、改善或治疗乳腺癌的组合物，根据本公开的一个实施方案，该组合物含有2,3,5-取代的噻吩化合物，具有抑制乳腺癌增殖的优异活性，特别是三阴性乳腺癌和赫赛汀耐药乳腺癌，这些癌症的死亡率很高，因为还没有有效的治疗方法。因此，本发明的组合物可以很好地用于预防、改善或治疗乳腺癌。
• USE OF 2,3,5-SUBSTITUTED THIOPHENE COMPOUND FOR ENHANCEMENT OF RADIOTHERAPY
  申请人：Pharos Ibio Co., Ltd.

  公开号：EP3804719A1

  公开（公告）日：2021-04-14

  The present disclosure relates to a composition for enhancing radiotherapy. The composition may increase the sensitivity of cancer cells to radiation, and thus may be advantageously used to enhance the effect of radiotherapy.

  本公开涉及一种用于增强放射治疗的组合物。该组合物可提高癌细胞对辐射的敏感性，因此可用于增强放疗效果。
• 2,3,5-substituted thiophene compound as protein kinase inhibitor
  申请人：KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US10442796B2

  公开（公告）日：2019-10-15

  The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent including the compound as an active ingredient, and a method for preparing the compound.

  本发明涉及一种对激酶具有抑制活性的新型 2,3,5-取代噻吩化合物、一种以该化合物为活性成分的抗癌剂以及制备该化合物的方法。
• NOVEL 2,3,5-SUBSTITUTED THIOPHENE COMPOUND AS PROTEIN KINASE INHIBITOR
  申请人：Korea Institute of Science and Technology

  公开号：EP3418275B1

  公开（公告）日：2021-03-17
• Novel 2,3,5-substituted thiophene compound as protein kinase inhibitor
  申请人：KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20190047993A1

  公开（公告）日：2019-02-14

  The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent including the compound as an active ingredient, and a method for preparing the compound.