(1R,2R)-N,N′-bis[thiophen-3-ylmethylidene]cyclohexane-1,2-diamine | 1598408-92-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: (1R,2R)-N,N′-bis[thiophen-3-ylmethylidene]cyclohexane-1,2-diamine
• CAS: 1598408-92-4
• 化学式: C₁₆H₁₈N₂S₂
• 分子量: 302.464
• InChiKey: CWTYZBDLPRZMFH-HZPDHXFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.66
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  24.72
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (1R,2R)-N,N′-bis[thiophen-3-ylmethylidene]cyclohexane-1,2-diamine 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以86%的产率得到(1R,2R)-N,N′-bis(thiophen-3-ylmethyl)cyclohexane-1,2-diamine
  参考文献：
  名称：

  Synthesis and fluorescent properties of novel chiral 1,2-diaminocyclohexane substituted ligands and their complexes

  摘要：

  A series of novel chiral 1,2-diaminocyclohexane derivatives bearing heterocyclic units were synthesized via improved methods under ultrasonic irradiation. The photophysical properties of compounds were studied in ethanol, methanol, and chloroform. The sensitivity of these amines toward Cu2+, Cd2+, and Ni2+ was studied by the UV vis and fluorescent methods. The pi-electron structure of thiophene and bithiophene containing sensors is the most active toward all above mentioned metal ions and is highly selective for Ni2+ and Cd2+. (c) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.02.092
• 作为产物：
  描述：

  3-噻吩甲醛 、 (1R,2R)-(+)-1,2-环己二胺 L-酒石酸盐 在 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 1.08h， 以90%的产率得到(1R,2R)-N,N′-bis[thiophen-3-ylmethylidene]cyclohexane-1,2-diamine
  参考文献：
  名称：

  Synthesis and fluorescent properties of novel chiral 1,2-diaminocyclohexane substituted ligands and their complexes

  摘要：

  A series of novel chiral 1,2-diaminocyclohexane derivatives bearing heterocyclic units were synthesized via improved methods under ultrasonic irradiation. The photophysical properties of compounds were studied in ethanol, methanol, and chloroform. The sensitivity of these amines toward Cu2+, Cd2+, and Ni2+ was studied by the UV vis and fluorescent methods. The pi-electron structure of thiophene and bithiophene containing sensors is the most active toward all above mentioned metal ions and is highly selective for Ni2+ and Cd2+. (c) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.02.092