(2,4-dichloro-phenoxy)-phenyl-acetic acid | 27469-44-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,4-dichloro-phenoxy)-phenyl-acetic acid
• 英文别名: (2,4-Dichlor-phenoxy)-phenyl-essigsaeure；(2,4-Dichlorophenoxy)(phenyl)acetic acid；2-(2,4-dichlorophenoxy)-2-phenylacetic acid
• CAS: 27469-44-9
• 化学式: C₁₄H₁₀Cl₂O₃
• mdl: MFCD09711204
• 分子量: 297.138
• InChiKey: SBJRFXFUGJZZGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Process for the preparation of 2-(2,4-dichlorophenoxy) phenylacetic acid
  申请人：RECKITT AND COLMAN PRODUCTS LIMITED

  公开号：EP0057047A1

  公开（公告）日：1982-08-04

  Process for the preparation of 2-(2,4-dichloro- phenoxy)phenylacetic acid in which the potassium salts of 2-chlorophenylacetic acid and 2,4-dichlorophenol are reacted in aromatic hydrocarbon solvents at elevated temperatures in the presence of a copper chloride catalyst, followed thereafter by acidification.

  制备 2-(2,4-二氯苯氧基)苯乙酸的工艺，其中 2-氯苯乙酸的钾盐和 2,4-二氯苯酚在芳香烃溶剂中，在氯化铜催化剂存在下，于高温下反应，然后酸化。
• Process for the preparation of 2-(2,4-dichlorophenoxy)phenylacetic acid
  申请人：Technobiotic Ltd.

  公开号：EP0068222A1

  公开（公告）日：1983-01-05

  Process for the preparation of 2-(2,4-dichlorophenoxy)-phenylacetic acid (a compound having useful anti-inflammatory properties) by reacting a 2-halo-phenylacetic acid or a salt thereof under basic conditions in the presence of metallic copper with 2,4-dichlorophenol or a salt thereof.

  制备 2-(2,4-二氯苯氧基)-苯乙酸（一种具有有效消炎特性的化合物）的工艺，其方法是在金属铜存在下，使 2-卤基苯乙酸或其盐在碱性条件下与 2,4-二氯苯酚或其盐反应。
• Uses of a substituted 2-phenoxyphenylacetic acid as an immunosuppressant drug
  申请人：Wood, Elizabeth May

  公开号：EP0297842A2

  公开（公告）日：1989-01-04

  Although fenclofenac (2-(2,4-dichloro-phenoxy) phenyl acetic acid) is known as an NSAID it has now been shown to have immunosuppressive properties indi­cating its usefulness in the treatment of a wide variety of conditions requiring immunosuppressive therapy. In this role fenclofenac may be combined with a prostaglandin and/or another immunosuppressive drug, and may be adminstered in a form for release in the terminal ileum or colon.

  尽管芬氯芬酸（2-(2,4-二氯苯氧基)苯乙酸）被称为非甾体抗炎药，但现在它已被证明具有免疫抑制特性，这表明它可用于治疗各种需要免疫抑制疗法的疾病。在这种情况下，芬氯芬酸可与前列腺素和/或另一种免疫抑制药物结合使用，并以在回肠末端或结肠释放的形式给药。
• Pyrimidinderivate, ihre Herstellung und Medikamente, die diese Derivate enthalten
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0257378B1

  公开（公告）日：1991-07-03
• Fenclofenac as TBP blocking agent in iodothyronine immunoassays
  申请人：MILES LABORATORIES, INC.

  公开号：EP0078477B1

  公开（公告）日：1986-09-10