3,4-Dibromopyridine-2-carbonitrile | 1381934-40-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3,4-Dibromopyridine-2-carbonitrile
• CAS: 1381934-40-2
• 化学式: C₆H₂Br₂N₂
• 分子量: 261.9
• InChiKey: XQGYZZXUAKAXRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  36.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• SUBSTITUTED IMIDAZOLYLMETHYL PYRIDINE AND PYRAZINE DERIVATIVES: GABA A RECEPTOR LIGANDS
  申请人：NEUROGEN CORPORATION

  公开号：EP1501825A2

  公开（公告）日：2005-02-02
• [EN] SUBSTITUTED IMIDAZOLYLMETHYL PYRIDINE AND PYRAZINE DERIVATIVES: GABAA RECEPTOR LIGANDS<br/>[FR] IMIDAZOLYLMETHYL PYRIDINE SUBSTITUEE ET DERIVES DE PYRAZINE: LES LIGANDS DES RECEPTEURS GABAA
  申请人：NEUROGEN CORP

  公开号：WO2004041809A2

  公开（公告）日：2004-05-21

  Substituted imidazolylmethyl pyridine and pyrazine derivatives that bind to GABAA receptors are provided. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).