1-benzylideneamino-5-methyl-imidazolidin-2-one | 56934-48-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-benzylideneamino-5-methyl-imidazolidin-2-one
• 英文别名: 1-(Benzylideneamino)-5-methylimidazolidin-2-one
• CAS: 56934-48-6
• 化学式: C₁₁H₁₃N₃O
• 分子量: 203.244
• InChiKey: DRPJZDCTLNLMGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  44.7
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• NOVEL PENAM DERIVATIVES OR SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
  申请人：FUJIFILM Corporation

  公开号：EP3778609A1

  公开（公告）日：2021-02-17

  An object of the present invention is to provide a compound and a pharmaceutical composition which exhibit strong antibacterial activity against Gram-negative bacteria and drug-resistant Gram-negative bacteria. A compound represented by General Formula [1] (the reference signs in Formula have the same definitions as those described in the present specification) or a salt thereof has strong antibacterial activity against Gram-negative bacteria such as Pseudomonas aeruginosa and drug-resistant Gram-negative bacteria including multidrug-resistant Pseudomonas aeruginosa, and the pharmaceutical composition containing the compound or a salt thereof is useful as an antibacterial agent.

  本发明的目的是提供一种对革兰氏阴性细菌和耐药革兰氏阴性细菌具有强抗菌活性的化合物和药物组合物。通式[1]代表的化合物（式中的参考符号与本说明书中描述的定义相同）或其盐对革兰氏阴性菌（如铜绿假单胞菌）和耐药革兰氏阴性菌（包括耐多药铜绿假单胞菌）具有很强的抗菌活性，含有该化合物或其盐的药物组合物可用作抗菌剂。
• PENAM DERIVATIVES OR SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
  申请人：FUJIFILM Corporation

  公开号：EP3778609B1

  公开（公告）日：2022-01-26