1-Chloro-3-[4-[1-[4-(3-chloro-2-hydroxypropoxy)phenyl]cyclohexyl]phenoxy]propan-2-ol | 1313877-91-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Chloro-3-[4-[1-[4-(3-chloro-2-hydroxypropoxy)phenyl]cyclohexyl]phenoxy]propan-2-ol
• CAS: 1313877-91-6
• 化学式: C₂₄H₃₀Cl₂O₄
• 分子量: 453.406
• InChiKey: NVXUSUGGXVLLGT-UHFFFAOYSA-N

物化性质

• 沸点：
  620.7±55.0 °C(Predicted)
• 密度：
  1.239±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  bisphenol Z diglycidyl ether 在 cerium(III) chloride heptahydrate 作用下， 以 乙腈 为溶剂， 反应 23.0h， 以53%的产率得到1-Chloro-3-[4-[1-[4-(3-chloro-2-hydroxypropoxy)phenyl]cyclohexyl]phenoxy]propan-2-ol
  参考文献：
  名称：

  [EN] BISPHENOL DERIVATIVES AND THEIR USE AS ANDROGEN RECEPTOR ACTIVITY MODULATORS
  [FR] DÉRIVÉS DU BISPHÉNOL ET LEUR UTILISATION EN TANT QUE MODULATEURS DE L'ACTIVITÉ DU RÉCEPTEUR DES ANDROGÈNES

  摘要：

  公开号：

  WO2011082487A8

文献信息

• BISPHENOL DERIVATIVES AND THEIR USE AS ANDROGEN RECEPTOR ACTIVITY MODULATORS
  申请人：British Columbia Cancer Agency Branch

  公开号：EP2521707B1

  公开（公告）日：2017-06-14
• METHODS FOR SYNTHESIZING HIGH PURITY EPOXY COMPOUNDS AND PRODUCTS OBTAINED THEREFROM
  申请人：SABIC GLOBAL TECHNOLOGIES B.V.

  公开号：US20190322653A1

  公开（公告）日：2019-10-24

  A process for preparing a diglycidyl ether of formula (1) to (9) with epichlorohydrin and a catalyst, for a time and at a temperature to provide a first reaction mixture comprising a dichlorohydrin of formula (1-d) to (9-d); adding a base to the first reaction mixture to provide a second reaction mixture over a period of 15 minutes to 3 hours; and agitating the second reaction mixture for 2 to 5 hours at 40 to 60° C., to provide an as-synthesized diglycidyl ether of formula (1) to (9) having a purity of 96 to 99% or greater as determined by high performance liquid chromatography is provided. An as-synthesized or isolated diglycidyl ether of formula (1) to (9) made by the provided process is provided. A cured composition comprising the cured product of the provided diglycidyl ether, and an article comprising the same are provided.
• US9388112B2
  申请人：——

  公开号：US9388112B2

  公开（公告）日：2016-07-12