(3α,5α)-17-methylene-androstan-3-ol | 203782-65-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (3α,5α)-17-methylene-androstan-3-ol
• 英文别名: 3α-hydroxy-10.13-dimethyl-17-methylene-5α-gonane；3α-Hydroxy-10.13-dimethyl-17-methylen-5α-gonan；(10S)-3t-Hydroxy-10r.13c-dimethyl-17-methylen-(5tH.8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren；(3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-methylidene-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-ol
• CAS: 203782-65-4
• 化学式: C₂₀H₃₂O
• 分子量: 288.473
• InChiKey: VOTJVLLIYSMTJZ-JIWXIQHESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (3α,5α)-17-methylene-androstan-3-ol 在 硼烷四氢呋喃络合物 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 23.5h， 生成 (3α,5α)-3-(methoxymethoxy)-androstane-17-methanol
  参考文献：
  名称：

  NEUROACTIVE 13, 17-SUBSTITUTED STEROIDS AS MODULATORS FOR GABA TYPE-A RECEPTORS

  摘要：

  本公开涉及神经活性的13,17-取代类固醇，以及其药用盐，例如作为麻醉剂使用，和/或用于治疗与GABA功能和活性相关的疾病。本公开还涉及包含这些化合物的药物组合物。

  公开号：

  US20140249120A1
• 作为产物：
  描述：

  nysted reagent 、 雄酮 在 四氯化钛 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 生成 (3α,5α)-17-methylene-androstan-3-ol
  参考文献：
  名称：

  对甲基睾酮和美二烯酮代谢的新见解：新型 A 环减少代谢物的检测

  摘要：

  美二烯酮和甲基睾酮是口服活性合成代谢雄激素类固醇，具有 17α-甲基结构，在体育运动中被禁止，但在反兴奋剂分析中经常被检测到。继之前报道在氯化间二烯酮类似物脱氢氯甲基睾酮（“口服特力补”）中检测到具有 17ψ-羟甲基-17ψ-甲基-18-nor-5ψ-androst-13-en-3ψ-ol 结构的长期代谢物后，在这项研究中，我们研究了具有重新排列的 D 环和完全还原的 A 环的间二烯酮和 17α-甲基睾酮的类似代谢物的形成。使用半靶向方法，包括合成参考化合物、两种非对映异构体物质，即。 17α-羟甲基-17β-甲基-18-nor-5β-androst-13-en-3α-ol 及其 5α-类似物在施用甲基睾酮后被鉴定。在美二酮给药后的尿液中，仅检测到 5β-代谢物。此外，除了筛选程序中包含的经典代谢物外，在两次给药的尿液中还鉴定出了 3α,5β-四氢表甲基睾酮。除了适用于反兴奋剂分析之外，这些结果还为

  DOI：

  10.3390/molecules26051354

文献信息

• [EN] ANDROSTANE AND PREGNANE SERIES FOR ALLOSTERIC MODULATION OF GABA RECEPTOR<br/>[FR] SERIES DE L'ANDROSTANE ET DE LA PREGNANE PRODUISANT UNE MODULATION ALLOSTERIQUE DU RECEPTEUR DU GABA
  申请人：COCENSYS, INC.

  公开号：WO1996016076A1

  公开（公告）日：1996-05-30

  (EN) Methods, compositions, and compounds for modulating the GABAA receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.(FR) Procédés, compositions et composés servant à moduler le complexe ionophore de chlorure et récepteur du GABAA, permettant ainsi d'atténuer le stress, l'anxiété, les crise d'épilepsie, les troubles de l'humeur, la dépression post natale et le syndrome prémenstruel, et de provoquer l'anesthésie.

  (中文) 用于调节GABAA受体-氯离子复合物以缓解压力、焦虑、癫痫、情绪障碍、PMS和PND并诱导麻醉的方法、组合物和化合物。
• Visible-light promoted de Mayo reaction by zirconium catalysis
  作者：Wenzhao Zhang、Sanzhong Luo

  DOI：10.1039/d2cc05029c

  日期：——

  Zirconium catalysis with ZrCl4 was developed to facilitate a de Mayo reaction under visible light conditions without any external photosensitizer and additive.

  开发了具有 ZrCl 4的锆催化以促进可见光条件下的 de Mayo 反应，而无需任何外部光敏剂和添加剂。
• Neuroactive 13, 17-substituted steroids as modulators for GABA type-A receptors
  申请人：Washington University

  公开号：US10160783B2

  公开（公告）日：2018-12-25

  The present disclosure is generally directed to neuroactive 13, 17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.

  本公开总体上涉及本文提及的神经活性 13、17-取代类固醇及其药学上可接受的盐类，可用作麻醉剂和/或治疗与 GABA 功能和活性有关的疾病。本公开进一步涉及包含此类化合物的药物组合物。
• Ultra-high-sensitive assay of protein and nucleic acid and kit, and novel enzyme substrate
  申请人：Ito Etsuro

  公开号：US11221299B2

  公开（公告）日：2022-01-11

  Provided is a ultra-high-sensitivity assay in which the assay can be made on a commonly used assay apparatus such as an absorptiometer and a plate reader or with naked eyes. The high-sensitivity assay in which the assay can be made on a commonly used assay apparatus or with naked eyes can be provided by combining an enzyme cycling method using thio-NAD(P) as a coenzyme, a labeling enzyme and a substrate for the labeling enzyme optimally, and by amplifying thio-NAD(P)H, which is a signaling substance, exponentially and then quantifying the thio-NAD(P)H colorimetrically.

  本发明提供了一种超高灵敏度检测方法，该方法可在常用的检测仪器（如吸收仪和平板阅读器）上或用肉眼进行检测。通过优化组合使用硫代-NAD(P)作为辅酶的酶循环方法、标记酶和标记酶底物，并通过指数放大作为信号物质的硫代-NAD(P)H，然后用比色法对硫代-NAD(P)H进行定量，可提供可在常用检测仪器上或用肉眼进行检测的高灵敏度检测方法。
• Facilitating Children's Understanding of Misinterpretation: Explanatory Efforts and Improvements in Perspective Taking
  作者：Bradford H. Pillow、Clay Mash、Samuel Aloian、Valerie Hill

  DOI：10.1080/00221320209598673

  日期：2002.6

  The authors investigated children's understanding of how mistaken beliefs can arise through misinterpretation of ambiguous information. Children (N = 91), aged 4 to 5 years, were given pre- and posttests on their ability to infer a puppet's interpretation of a restricted-view drawing after the puppet had been led to an erroneous expectation about the drawing's identity. Before the posttest, the children received either self-explanation training or other-explanation training in which they explained the source of their own or a puppet's misinterpretations of drawings; a control group received no training. The children who received training improved from pre- to posttest, and those who had practiced explaining misinterpretations by referring to previously viewed pictures or to features of a target picture showed the greatest improvement. These results indicate that learning to explain misinterpretations can help children recognize situations in which misinterpretations are likely to occur.