4-(4-Carboxybutyl)benzoic acid | 412281-97-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-Carboxybutyl)benzoic acid
• CAS: 412281-97-1
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.24
• InChiKey: ZPVPUPDCZVRBMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Substituted Spiro-amide Compounds
  申请人：Schunk Stefan

  公开号：US20100249095A1

  公开（公告）日：2010-09-30

  Substituted spiro-amide compounds corresponding to formula I in which R5 through R8, D, X, Y and Z have defined meanings, processes for preparing such spiro-amide compounds, pharmaceutical compositions containing such compounds, and methods of using such spiro-amide compounds for treating and/or inhibiting disorders or disease states mediated at least in part by the bradykinin 1 receptor.

  将与式I相对应的螺环酰胺化合物替代为R5至R8、D、X、Y和Z具有定义含义的过程，用于制备这种螺环酰胺化合物，含有这种化合物的药物组合物，以及使用这种螺环酰胺化合物治疗和/或抑制至少部分由激肽酶1受体介导的疾病或疾病状态的方法。
• PROTEASE STABILIZED, ACYLATED INSULIN ANALOGUES
  申请人：Novo Nordisk A/S

  公开号：US20140073564A1

  公开（公告）日：2014-03-13

  Novel acylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain B25H and A14E or A14H.

  新型酰化胰岛素类似物表现出对蛋白酶的抵抗力，可以有效地通过肺部或口服给药。胰岛素类似物包含B25H和A14E或A14H。
• Substituted Spiro-Amide Compounds
  申请人：Gruenenthal GmbH

  公开号：US20130231327A1

  公开（公告）日：2013-09-05

  Substituted spiro-amide compounds corresponding to formula I in which R 5 through R 8 , D, X, Y and Z have defined meanings, processes for preparing such spiro-amide compounds, pharmaceutical compositions containing such compounds, and methods of using such spiro-amide compounds for treating and/or inhibiting disorders or disease states mediated at least in part by the bradykinin 1 receptor.

  本发明提供了对应于式I的取代螺环酰胺化合物，其中R5至R8、D、X、Y和Z具有定义的含义，制备这种螺环酰胺化合物的过程，含有这种化合物的药物组合物以及使用这种螺环酰胺化合物治疗和/或抑制至少部分由激肽酶1受体介导的疾病或疾病状态的方法。
• PROTEASE STABILIZED ACYLATED INSULIN ANALOGUES
  申请人：NOVO NORDISK A/S

  公开号：US20150210748A1

  公开（公告）日：2015-07-30

  Novel acylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain B25H and A14E or A14H.

  具有对蛋白酶抗性的新型酰化胰岛素类似物可以有效地通过肺部或口服给药。胰岛素类似物包含B25H和A14E或A14H。
• Insulin Derivatives Containing Additional Disulfide Bonds
  申请人：Madsen Peter

  公开号：US20130157938A1

  公开（公告）日：2013-06-20

  The present invention is related to insulin derivatives containing additional disulfide bonds and methods of making such.