2-acetoxy-5-acetylamino-2,3-dihydro-phthalazine-1,4-dione | 15371-00-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-acetoxy-5-acetylamino-2,3-dihydro-phthalazine-1,4-dione
• 英文别名: N-(2-acetyl-1,4-dioxo-1,2,3,4-tetrahydro-phthalazin-5-yl)-acetamide；N-(2-Acetyl-1,4-dioxo-1,2,3,4-tetrahydro-phthalazin-5-yl)-acetamid；5-Acetylamino-2-acetyl-phthalaz-1,4-dion
• CAS: 15371-00-3
• 化学式: C₁₂H₁₁N₃O₄
• 分子量: 261.237
• InChiKey: GRTJOONIYCFUDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.31
• 重原子数：
  19.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  101.03
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-acetoxy-5-acetylamino-2,3-dihydro-phthalazine-1,4-dione 在 ammonium hydroxide 作用下， 生成 N5-ethanoyl-5-amino-2,3-dihydrophthalazine-1,4-dione
  参考文献：
  名称：

  Persistent, Consistent, Widespread, and Robust? Another Look at Recent Trends in Old-Age Disability

  摘要：

  Objective. The purpose of this study was to provide new evidence on disability trends among elderly persons from 1982 to 1996.Methods. The sample includes 125,949 participants aged 70 and older in the 1982-1996 National Health Interview Surveys. Logistic analysis was used to estimate the trend in disability prevalence after controlling for various sociodemographic factors.Results. We found that: (a) the prevalence of disability has declined, but the gains did not persist throughout the entire period or accelerate over time: (b) only routine care disability has declined. whereas more severe personal care disability shows no improvements; (c) estimates are robust to the exclusion of the nursing home population but may be sensitive to growth in the assisted living population: (d) estimates of decline in disability prevalence are fairly consistent across five national surveys: (e) gains have been concentrated among the most educated elderly persons: and (F) gains in education appear to be an important confounder of the improvements.Discussion. Evidence from several surveys using various measures indicate that disability has declined among elderly persons. Determining the causes of the improvements should be a high priority in future research efforts.

  DOI：

  10.1093/geronb/56.4.s206
• 作为产物：
  描述：

  乙酸酐 、 alkaline earth salt of/the/ methylsulfuric acid 生成 2-acetoxy-5-acetylamino-2,3-dihydro-phthalazine-1,4-dione
  参考文献：
  名称：

  Persistent, Consistent, Widespread, and Robust? Another Look at Recent Trends in Old-Age Disability

  摘要：

  Objective. The purpose of this study was to provide new evidence on disability trends among elderly persons from 1982 to 1996.Methods. The sample includes 125,949 participants aged 70 and older in the 1982-1996 National Health Interview Surveys. Logistic analysis was used to estimate the trend in disability prevalence after controlling for various sociodemographic factors.Results. We found that: (a) the prevalence of disability has declined, but the gains did not persist throughout the entire period or accelerate over time: (b) only routine care disability has declined. whereas more severe personal care disability shows no improvements; (c) estimates are robust to the exclusion of the nursing home population but may be sensitive to growth in the assisted living population: (d) estimates of decline in disability prevalence are fairly consistent across five national surveys: (e) gains have been concentrated among the most educated elderly persons: and (F) gains in education appear to be an important confounder of the improvements.Discussion. Evidence from several surveys using various measures indicate that disability has declined among elderly persons. Determining the causes of the improvements should be a high priority in future research efforts.

  DOI：

  10.1093/geronb/56.4.s206

文献信息

• The Chemiluminescence of Luminol and Acetyl-luminol
  作者：Yoshimori Omote、Takeo Miyake、Seiya Ohmori、Noboru Sugiyama

  DOI：10.1246/bcsj.40.899

  日期：1967.4

  Several acetyl derivatives of luminol were synthesized and their chemiluminescence were studied in water or in DMF-water. The role of the amino group in the chemiluminescence was revealed by comparing the chemiluminescence of luminol (I) with that of N-acetyl-luminol (II). Also, it was found that, in the case of the chemiluminescence of I or II in water, the emitting species did not seem to be the

  合成了几种鲁米诺的乙酰衍生物，并在水中或在 DMF 水中研究了它们的化学发光。通过比较鲁米诺 (I) 的化学发光与 N-乙酰-鲁米诺 (II) 的化学发光，揭示了氨基在化学发光中的作用。此外，还发现，在 I 或 II 在水中的化学发光的情况下，发射物种似乎不是相应的取代邻苯二甲酸根离子，而在 DMF-水中的化学发光的情况下，3-氨基邻苯二甲酸盐或 3-乙酰氨基邻苯二甲酸盐离子可以被假定为发射物种。