3-phenylsulfanylbenzamide | 106380-90-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-phenylsulfanylbenzamide
• 英文别名: 3-(Phenylsulfanyl)benzamide
• CAS: 106380-90-9
• 化学式: C₁₃H₁₁NOS
• 分子量: 229.302
• InChiKey: KLZFWPYDNDTTGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-(苯硫基)苯甲酸 生成 3-phenylsulfanylbenzamide
  参考文献：
  名称：

  The von Richter Reaction. III. Substituent Effects^1,2

  摘要：

  DOI：

  10.1021/jo01115a004

文献信息

• A General and Long-Lived Catalyst for the Palladium-Catalyzed Coupling of Aryl Halides with Thiols
  作者：Manuel A. Fernández-Rodríguez、Qilong Shen、John F. Hartwig

  DOI：10.1021/ja0580340

  日期：2006.2.1

  general catalytic system for the coupling of aryl halides and sulfonates with thiols based on the use of the CyPF-t-Bu ligand (1) is reported. The reactions catalyzed by complexes of 1 occur in excellent yields with broad scope and exhibit extraordinary turnover numbers and high tolerance of functional groups. Turnover numbers usually exceed those of previous catalysts by 2 or 3 orders of magnitude.

  报道了基于使用 CyPF-t-Bu 配体 (1) 将芳基卤化物和磺酸盐与硫醇偶联的通用催化系统。由 1 的配合物催化的反应以优异的产率和广泛的范围发生，并表现出非凡的转换数和高官能团耐受性。营业额通常比以前的催化剂高出 2 或 3 个数量级。此外，首次报道了芳基甲苯磺酸酯与烷烃硫醇形成芳基硫化物的反应。最后，使用硫化氢替代物完成了由两种溴芳烃合成二芳基硫化物。
• Highly Efficient and Functional-Group-Tolerant Catalysts for the Palladium-Catalyzed Coupling of Aryl Chlorides with Thiols
  作者：Manuel A. Fernández-Rodríguez、Qilong Shen、John F. Hartwig

  DOI：10.1002/chem.200600949

  日期：2006.10.16

  The cross-coupling reaction of aryl chlorides with aliphatic and aromatic thiols catalyzed by palladium complexes of the strongly binding bisphosphine CyPF-tBu ligand (1) is reported. Most of the reactions catalyzed by complexes of ligand 1 occur with turnover numbers that exceed those of previous catalysts by two orders of magnitude. The reactions occur with excellent yields, broad scope and high

  据报道，芳基氯化物与强结合双膦CyPF-tBu配体（1）的钯配合物催化的脂族和芳族硫醇的交叉偶联反应。由配体1的配合物催化的大多数反应发生的周转数比先前催化剂的周转数高两个数量级。反应以优异的收率，广泛的范围和对官能团的高耐受性进行。还描述了在低负载量下衍生自其他Josiphos型配体以及其他结构类型的配体的芳基卤化物与硫醇的偶联。
• Polyimide precursor resin composition and semiconductor device using the same
  申请人：Hitachi Chemical Co., Ltd.

  公开号：EP0184937A2

  公开（公告）日：1986-06-18

  A polyimide precursor resin composition comprising (a) a poly(amic acid) containing siloxane linkages, (b) an aminosilane, and (c) a solvent for both the components (a) and (b), can form a polyimide film excellent in adhesiveness and heat resistance and is suitable for producing a semiconductor device having high reliability.

  一种聚酰亚胺前体树脂组合物由以下成分组成：(a) 含硅氧烷链节的聚(氨基)酸；(b) 氨基硅烷；(c) 成分(a)和(b)的溶剂，这种组合物可以形成粘合性和耐热性极佳的聚酰亚胺薄膜，适用于生产可靠性高的半导体器件。
• Vinblastine 20″ amides: synthetic analogs that maintain or improve potency and simultaneously overcome Pgp-derived efflux and resistance
  申请人：The Scripps Research Institute

  公开号：US10689381B2

  公开（公告）日：2020-06-23

  A vinca alkaloid compound substituted at the 20′-position with a carboxamido group is disclosed. The carbonyl of the carboxamido group is bonded to a 20′-amino group and to a ring system that contains up to three 5-, 6- or 7-membered rings that are fused or otherwise bonded together. Each ring can be carbocyclic or heterocyclic, with a heterocyclic ring containing up to three hetero ring atoms that are the same or different and are selected from nitrogen, oxygen and sulfur. The ring system can include up to four substituent groups other than hydrogen that are discussed within. Methods of preparing the compounds are disclosed as are compositions for their use and methods of treatment using d compound. A particularly preferred compound has an activity in specified cancer cell growth inhibition assays that is the same or better than its parental, unsubstituted vinca compound and is not subject to Pgp-mediated efflux.

  本发明公开了一种在 20′位被羧酰胺基取代的长春花生物碱化合物。羧酰胺基团的羰基与 20′-氨基基团和一个环系统键合，该环系统包含最多三个融合或以其他方式键合在一起的 5、6 或 7 元环。每个环可以是碳环或杂环，其中杂环含有最多三个相同或不同的杂环原子，这些原子选自氮、氧和硫。除氢外，该环系还可包括多达四个取代基团。公开了制备化合物的方法以及使用这些化合物的组合物和使用 d 化合物进行治疗的方法。一种特别优选的化合物在特定癌细胞生长抑制实验中的活性与其亲本未取代的长春花化合物相同或更好，并且不受 Pgp 介导的外流影响。
• Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
  申请人：NERVIANO MEDICAL SCIENCES S.R.L.

  公开号：EP2266987B1

  公开（公告）日：2017-05-17