thiobenzoic acid ammonium salt | 81666-85-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: thiobenzoic acid ammonium salt
• 英文别名: Thiobenzoesaeure; Ammonium-Salz；Azanium;thiobenzate
• CAS: 81666-85-5
• 化学式: C₇H₆OS*H₃N
• 分子量: 155.221
• InChiKey: OIQBDCOBCGTZBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.92
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  19.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  thiobenzoic acid ammonium salt 、 吡噻硫酮 以 氯仿 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  [EN] ROTOMERIC ISOMERS OF 4-ALKYL-5-HETEROARYL-3H-1,2-DITHIOLE-3-THIONES
  [FR] ISOMÈRES ROTAMÈRES DE 4-ALKYL-5-HÉTÉROARYL-3H-1,2-DITHIOLE-3-THIONES

  摘要：

  本公开提供了4-烷基-1-5-杂环芳基-3H-1,2-二硫杂环-3-硫酮的转构异构体，其中通过稳定化获得单个转构形式的这种异构体的复合物，以及包含单个旋转体的过量（旋转体过量）的稳定化复合物的组合物。本公开还涉及制备和使用这些旋转体和复合物的方法，包括使用这些旋转体或其复合物治疗人类或动物患者的方法，例如预防、治疗或减轻各种疾病的症状，如黏膜炎、病毒感染、中风损伤、缺血/再灌注损伤、心脏缺血和/或在各种器官和组织中提供对氧化损伤的保护等医疗目的。

  公开号：

  WO2021186244A1

文献信息

• WO2020058767A5
  申请人：——

  公开号：WO2020058767A5

  公开（公告）日：2022-09-26
• ROTOMERIC ISOMERS OF 4-ALKYL-5-HETEROARYL-3H-1,2- DITHIOLE-3-THIONES
  申请人：ST IP Holding AG

  公开号：EP3853223A1

  公开（公告）日：2021-07-28
• Rotomeric Isomers of 4-alkyl-5-Heteroaryl-3H-1,2-Dithiole-3-Thiones
  申请人：ST IP HOLDING AG

  公开号：US20210206751A1

  公开（公告）日：2021-07-08

  This disclosure provides, among other things, rotomeric isomers of 4-alkyl-5-heteroaryl-3H-1,2-dithiole-3-thiones, complexes of such isomers in which an individual rotomeric form is obtained by stabilization, and compositions comprising an excess of an individual rotomer (a rotomeric excess) as a stabilized complex. The disclosure also relates to methods of making and using: such rotomers and complexes, including methods of treating a human or animal patient with such rotomers or complexes thereof, e.g., to prevent, treat or reduce the symptoms of various disorders such as mucositis, and/or provide protection against oxidative damage in various organs and tissues for a medical purpose.
• [EN] ROTOMERIC ISOMERS OF 4-ALKYL-5-HETEROARYL-3H-1,2- DITHIOLE-3-THIONES<br/>[FR] ISOMÈRES ROTAMÈRES DE 4-ALKYL-5-HÉTÉROARYL-3H-1,2-DITHIOLE-3-THIONES
  申请人：ST IP HOLDING AG

  公开号：WO2020058767A1

  公开（公告）日：2020-03-26

  This disclosure provides, among other things, rotomeric isomers of 4-alkyl-5-heteroaryl-3H-1,2-dithiole-3-thiones, complexes of such isomers in which an individual rotomeric form is obtained by stabilization, and compositions comprising an excess of an individual rotomer (a rotomeric excess) as a stabilized complex. The disclosure also relates to methods of making and using: such rotomers and complexes, including methods of treating a human or animal patient with such rotomers or complexes thereof, e.g., to prevent, treat or reduce the symptoms of various disorders such as mucositis, and/or provide protection against oxidative damage in various organs and tissues for a medical purpose.