ethyl 8,9-difluoro-4-methyl-1-oxo-1,4-dihydrobenzo[f] [1,7]naphthyridine-2-carboxylate | 318684-67-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: ethyl 8,9-difluoro-4-methyl-1-oxo-1,4-dihydrobenzo[f] [1,7]naphthyridine-2-carboxylate
• 英文别名: Ethyl 8,9-difluoro-4-methyl-1-oxo-1,4-dihydrobenzo[f][1,7]naphthyridine-2-carboxylate；ethyl 8,9-difluoro-4-methyl-1-oxobenzo[f][1,7]naphthyridine-2-carboxylate
• CAS: 318684-67-2
• 化学式: C₁₆H₁₂F₂N₂O₃
• 分子量: 318.28
• InChiKey: ORBSRYJVFXQTNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  59.5
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  ethyl 8,9-difluoro-4-methyl-1-oxo-1,4-dihydrobenzo[f] [1,7]naphthyridine-2-carboxylate 在 氢氧化钾 作用下， 以 乙醇 、 二甲基亚砜 为溶剂， 生成 8-Fluoro-4-methyl-1-oxo-9-(1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl)benzo[f][1,7]naphthyridine-2-carboxylic acid
  参考文献：
  名称：

  Benzo[f]naphtyridones: a new family of topical antibacterial agents active on multi-resistant Gram-positive pathogens

  摘要：

  The synthesis and antibacterial activity of benzo[f][1,7]naphtyridone derivatives are reported. These compounds are potent antibacterial agents with a Gram-positive spectrum of activity. They are active against multi-resistant cocci, especially Staphylococcus aureus strains. Their physico-chemical and biological properties make them particularly suitable for topical antibacterial use. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00057-x
• 作为产物：
  描述：

  ethyl 8,9-difluoro-4-oxo-1,4-dihydrobenzo[f] [1,7]naphthyridine-2-carboxylate 、 γ,γ-dichloropropanol 、 碘甲烷 在 potassium carbonate 作用下， 以 二氯甲烷 、 水 、 甲烷 、 二甲基亚砜 为溶剂， 生成 ethyl 8,9-difluoro-1-oxo-1,4-dihydrobenzo[f] [1,7]naphthyridine-2-carboxylate 、 ethyl 8,9-difluoro-4-methyl-1-oxo-1,4-dihydrobenzo[f] [1,7]naphthyridine-2-carboxylate
  参考文献：
  名称：

  Benzo[f]naphthyridine derivatives, their preparation and compositions containing them

  摘要：

  苯并［ｆ］萘啉衍生物的化学式（I）：1苯并［ｆ］萘啉衍生物和苯并［ｆ］萘啉酯的化学式（IVa）；2氨基喹啉衍生物的化学式（X）；3制备这些化合物的方法；以及包含它们的组合物。

  公开号：

  US20020137741A1

文献信息

• Benzo[f]naphthyridine derivatives, their preparation and compositions containing them
  申请人：Aventis Pharma S.A.

  公开号：US06566362B2

  公开（公告）日：2003-05-20

  Benzo[f]naphthyridine derivatives of formula (I): benzo[f]naphthyridine derivatives and benzo[f]naphthyridine esters of formula (IVa): aminoquinoline derivatives of formula (X): processes for preparing such compounds; and compositions comprising them.

  本文介绍了公式（I）的苯并[f]萘啉衍生物，公式（IVa）的苯并[f]萘啉酯衍生物和公式（X）的氨基喹啉衍生物，以及制备这些化合物的过程和包含它们的组合物。
• US6566362B2
  申请人：——

  公开号：US6566362B2

  公开（公告）日：2003-05-20
• Benzo[f]naphthyridine derivatives, their preparation and compositions containing them
  申请人：——

  公开号：US20020137741A1

  公开（公告）日：2002-09-26

  Benzo[f]naphthyridine derivatives of formula (I): 1 benzo[f]naphthyridine derivatives and benzo[f]naphthyridine esters of formula (IVa): 2 aminoquinoline derivatives of formula (X): 3 processes for preparing such compounds; and compositions comprising them.

  苯并［ｆ］萘啉衍生物的化学式（I）：1苯并［ｆ］萘啉衍生物和苯并［ｆ］萘啉酯的化学式（IVa）；2氨基喹啉衍生物的化学式（X）；3制备这些化合物的方法；以及包含它们的组合物。
• Benzo[f]naphtyridones: a new family of topical antibacterial agents active on multi-resistant Gram-positive pathogens
  作者：Michel Tabart、Guy Picaut、Marc Lavergne、Sylvie Wentzler、Jean-Luc Malleron、Sylvie Dutka-Malen、Nadine Berthaud

  DOI：10.1016/s0960-894x(03)00057-x

  日期：2003.4

  The synthesis and antibacterial activity of benzo[f][1,7]naphtyridone derivatives are reported. These compounds are potent antibacterial agents with a Gram-positive spectrum of activity. They are active against multi-resistant cocci, especially Staphylococcus aureus strains. Their physico-chemical and biological properties make them particularly suitable for topical antibacterial use. (C) 2003 Elsevier Science Ltd. All rights reserved.