4-硝基苯基甲基丙烯酸甲酯 | 16522-41-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 中文名称: 4-硝基苯基甲基丙烯酸甲酯
• 英文名称: 4-nitrophenyl methacrylate
• 英文别名: p-nitrophenyl methacrylate；(4-nitrophenyl) 2-methylprop-2-enoate
• CAS: 16522-41-1
• 化学式: C₁₀H₉NO₄
• mdl: MFCD00080590
• 分子量: 207.186
• InChiKey: NACSMDAZDYUKMU-UHFFFAOYSA-N

物化性质

• 熔点：
  93-94 °C
• 沸点：
  345.4±21.0 °C(Predicted)
• 密度：
  1.241±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 危险类别码：
  R36/37/38
• 安全说明：
  S26,S36/37/39

反应信息

• 作为反应物：
  描述：

  4-硝基苯基甲基丙烯酸甲酯 以88%的产率得到
  参考文献：
  名称：

  BARBA, N. A.;VLAD, V. P.;VLAD, L. A., METALLXELATY I IX SVOJSTVA: VOPR. XIMII I XIM. TEXNOL., KISHINEV, 1985, 7+

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基丙烯酰氯 以74%的产率得到
  参考文献：
  名称：

  BANKS A. R.; FIBIGER R. F.; JONES T., J. ORG. CHEM., 1977, 42, NO 24, 3965-3966

  摘要：

  DOI：

文献信息

• [EN] FORCE-RESPONSIVE POLYMERSOMES AND NANOREACTORS; PROCESSES UTILIZING THE SAME<br/>[FR] POLYMERSOMES ET NANORÉACTEURS SENSIBLES À LA FORCE; PROCÉDÉS LES UTILISANT
  申请人：ADOLPHE MERKLE INSTITUTE UNIV OF FRIBOURG

  公开号：WO2019034597A1

  公开（公告）日：2019-02-21

  The mechanically induced melting properties of DNA were employed to achieve force labile membranes is described. Nucleobase pairs were used as mechanophores. Adenine and thymine functionalized complementary amphiphilic block copolymers were self-assembled into polymersomes. The nucleobases formed hydrogen bonds which were disrupted upon force stimulation. The exposure of the disconnected nucleobases to the hydrophobic matrix of the membranes lead to a change of permeability which permitted the exchange of water-soluble molecules throughout the polymer matrix. Moreover, the encapsulation of horseradish peroxidase enabled the reaction of luminol with hydrogen peroxide to yield a luminescence producing species similar to the marine bioluminescence. Moreover, the same nano-reactors were employed to catalyze the formation of a polyacrylamide gel when force was applied. Insights into the change of permeability of supramolecular networks upon force are provided. These systems are useful for drug delivery, as nanoreactors and for the selective release of curing agents for 3D printing, or fragrances.

  DNA的机械诱导熔化特性被用来实现易受力破裂的膜。核碱基对被用作机械感受器。腺嘌呤和胸腺嘧啶功能化的互补两性分块共聚物自组装成聚合体囊。核碱基形成氢键，在受力刺激下被破坏。断开的核碱基暴露在膜的疏水基质中，导致渗透性的改变，从而允许水溶性分子在聚合物基质中交换。此外，封装辣根过氧化物酶使得辣根酰胺与过氧化氢反应产生类似海洋生物发光的发光物种。此外，当施加力时，相同的纳米反应器被用来催化聚丙烯酰胺凝胶的形成。提供了关于受力下超分子网络渗透性变化的见解。这些系统可用于药物传递、纳米反应器以及用于3D打印的固化剂或香料的选择性释放。
• Isothiourea-catalysed transfer hydrogenation of α,β-unsaturated para-nitrophenyl esters
  作者：Jiufeng Wu、Claire M. Young、Andrew D. Smith

  DOI：10.1016/j.tet.2020.131758

  日期：2021.1

  transfer hydrogenation of α,β-unsaturated para-nitrophenyl esters using Hantzsch ester has been developed. Good to excellent yields are observed using α,β-unsaturated aryl esters bearing electron-withdrawing β-substituents. The aryl ester products can either be isolated directly in moderate to excellent yields (7 examples, 16–98%) or converted to the corresponding methyl esters (2 examples, 68–70% yield)

  已开发出使用Hantzsch酯的异硫脲催化的α，β-不饱和对硝基苯酯转移氢化的方案。使用带有吸电子β-取代基的α，β-不饱和芳基酯，观察到良好至优异的产率。可以直接分离出芳基酯产物，以中等至优异的收率（7例，产率为16–98％）或转化为相应的甲酯（2例，产率为68–70％）或苄基酰胺（2例，44-88）。氢化酯与适当的亲核试剂进行原位反应后得到 初步实验表明，当使用手性异硫脲催化剂时，适度的对映体诱导（76:24 er）是可能的。
• The Reactivities of Nuclear-Substituted Phenyl Methacrylates in Radical Copolymerization with Styrene
  作者：Takayuki Otsu、Toshio Ito、Yoshihiro Fujii、Minoru Imoto

  DOI：10.1246/bcsj.41.204

  日期：1968.1

  reactivities of methacrylate monomers toward the attack of a radical, the copolymerizations of a series of nuclear-substituted phenyl methacrylates with styrene were investigated. From the results, the monomer reactivity ratios and the Alfrey-Price Q, and e values were determined. It was found that the relative reactivities toward the polystyryl radical were not correlated with the ordinary Hammett equation

  为了阐明烷基取代基对甲基丙烯酸酯单体对自由基攻击的反应性的影响，研究了一系列核取代的甲基丙烯酸苯酯与苯乙烯的共聚反应。根据结果​​，确定了单体反应性比率和 Alfrey-Price Q 和 e 值。发现对聚苯乙烯基团的相对反应性与普通的哈米特方程无关，但通过包含取​​代基共振贡献项的修正哈米特方程获得了线性关系。因此，认为取代的甲基丙烯酸苯酯的反应性取决于由取代基引起的极性和共振效应。
• Functionalized Photoreactive Compounds
  申请人：Cherkaoui Mohammed Zoubair

  公开号：US20080274304A1

  公开（公告）日：2008-11-06

  The present invention concerns functionalized photoreactive compounds of formula (I), that are particularly useful in materials for the alignment of liquid crystals. Due to the adjunction of an electron withdrawing group to specific molecular systems bearing an unsaturation directly attached to two unsaturated ring systems, exceptionally high photosensitivities, excellent alignment properties as well as good mechanical robustness could be achieved in materials comprising said functionalized photoreactive compounds of the invention.

  本发明涉及式(I)的官能化光反应化合物，特别适用于液晶对准材料。由于在特定分子系统中的不饱和键直接连接到两个不饱和环系统上附加了一个电子受体基团，因此在包含本发明的这些官能化光反应化合物的材料中可以实现异常高的光敏性、优异的对准性能以及良好的机械稳健性。
• pH响应型纳米药物递送系统及其制备方法
  申请人：西北师范大学

  公开号：CN111991563A

  公开（公告）日：2020-11-27

  一种具有pH响应型的纳米药物递送载体，是合成嵌段聚合物P(ALD)‑g‑DOX‑b‑P(PEG)‑b‑PBA‑VI,通过酯交换反应使对羟基苯甲醛取代对硝基苯酚，有效保护醛基在聚合时强氧化环境中不被氧化。端位的醛基与盐酸阿霉素上氨基发生席夫碱反应生成酸敏感的亚胺键，以键联的方式携带药物。聚合物中咪唑基团配位CdTe量子点用于光动力学治疗,苯硼酸作为特异性靶向配体。本发明的纳米胶束具有良好的pH响应性，负载的DOX能在肿瘤细胞弱酸性环境中释放，有望成为良好的药物递送系统。