5-(2-benzyloxy-3-methoxyphenyl)-1-(4-fluoro-2-trifluoromethylbenzyl)-1H-1,2,3,4-tetrazole | 512183-32-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-(2-benzyloxy-3-methoxyphenyl)-1-(4-fluoro-2-trifluoromethylbenzyl)-1H-1,2,3,4-tetrazole
• 英文别名: 1-[[4-Fluoro-2-(trifluoromethyl)phenyl]methyl]-5-(3-methoxy-2-phenylmethoxyphenyl)tetrazole
• CAS: 512183-32-3
• 化学式: C₂₃H₁₈F₄N₄O₂
• 分子量: 458.415
• InChiKey: TZUCPDYOLDJHCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  62.1
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• REMEDIES FOR STRESS DISEASES COMPRISING MITOCHONDRIAL BENZODIAZEPINE RECEPTOR ANTAGONISTS
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1438973A1

  公开（公告）日：2004-07-21

  A pharmaceutical composition for the prophylaxis and/or treatment of diseases induced, exacerbated or reignited by stressors comprising the compound of formula (I) wherein all symbols have the same meanings as described in the specification, etc. as an active ingredient.

  一种用于预防和/或治疗由应激源诱发、加重或复燃的疾病的药物组合物，由式 (I) 化合物组成 其中所有符号的含义与说明书中所述的相同等作为活性成分。
• PHARMACEUTICAL COMPOSITIONS CONTAINING AN HIV INTEGRASE INHIBITOR AND A NONIONIC SURFACTANT
  申请人：Merck & Co., Inc.

  公开号：EP1499391A2

  公开（公告）日：2005-01-26
• Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists
  申请人：Seko Takuya

  公开号：US20050009812A1

  公开（公告）日：2005-01-13

  A pharmaceutical composition for the prophylaxis and/or treatment of diseases induced, exacerbated or reignited by stressors comprising the compound of formula (I) wherein all symbols have the same meanings as described in the specification, etc. as an active ingredient.
• [EN] PHARMACEUTICAL COMPOSITIONS CONTAINING AN HIV INTEGRASE INHIBITOR AND A NONIONIC SURFACTANT<br/>[FR] COMPOSITIONS PHARMACEUTIQUES CONTENANT UN INHIBITEUR DE L'INTEGRASE DU VIH ET UN TENSIOACTIF NON IONIQUE
  申请人：MERCK & CO INC

  公开号：WO2003086319A2

  公开（公告）日：2003-10-23

  Pharmaceutical compositions comprise a therapeutically effective amount of an 8-hydroxy-1,6-naphthyridine-7-carboxamide of Formula (I), or a pharmaceutically acceptable salt thereof: (I);and a nonionic surfactant; wherein R1, R2, R3 and Q1 are defined herein. Compounds of Formula (I) are HIV integrase inhibitors, and the pharmaceutical compositions are useful for preventing or treating HIV infection or for preventing, treating, or delaying the onset of AIDS. The pharmaceutical compositions are typically administered orally, for example, in the form of capsules or tablets, and can provide good oral bioavailability. Methods for preparing encapsulated and tabletted forms of the pharmaceutical compositions are described.