(+/-)-cis-N1-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine | 365996-27-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (+/-)-cis-N1-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine
• 英文别名: N-[(1S,2R)-2-aminocyclohexyl]-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxamide
• CAS: 365996-27-6
• 化学式: C₁₄H₂₂N₄OS
• 分子量: 294.421
• InChiKey: PSMGFOGNPRGVJV-ZJUUUORDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  99.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (+/-)-cis-N1-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine 生成 (1R,2S)-N1-[(5-Chloroindol-2-yl)carbonyl]-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-carbonyl]-1,2-cyclohexanediamine
  参考文献：
  名称：

  ETHYLENEDIAMINE DERIVATIVES

  摘要：

  公开号：

  EP1270557B1

文献信息

• Ethylenediamine derivatives
  申请人：——

  公开号：US20040122063A1

  公开（公告）日：2004-06-24

  The invention relates a compound represented by the formula (1): Q 1 -Q 2 -C(═O)—N(R 1 )-Q 3 -N(R 2 )-T 1 -Q 4 ( 1 ) wherein R 1 and R 2 represent H or the like; Q 1 represents an aromatic ring, heterocyclic ring or the like; Q 2 represents a single bond, aromatic ring, heterocyclic ring or the like; Q 3 represents a group 1 or the like, Q 4 represents an aromatic ring, heterocyclic ring or the like; and T 1 represents —CO— or —SO 2 —, and a medicine which comprises the compound and is useful for thrombosis and embolism.

  本发明涉及一种由式（1）表示的化合物：Q1-Q2-C(═O)—N(R1)-Q3-N(R2)-T1-Q4(1)，其中R1和R2代表H或类似物；Q1代表芳香环，杂环或类似物；Q2代表单键，芳香环，杂环或类似物；Q3代表群1或类似物，Q4代表芳香环，杂环或类似物；T1代表—CO—或—SO2—，以及包含该化合物并对治疗血栓和栓塞有用的药物。
• Monoacylated 1,2-diaminocycloalkanes
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP2431370A1

  公开（公告）日：2012-03-21

  Compounds represented by the following general formula (9): The compounds (9) are synthetic intermediates of pharmacologically active products.

  以下通式(9)所代表的化合物： 化合物（9）是药理活性产品的合成中间体。
• Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors
  作者：Tsutomu Nagata、Toshiharu Yoshino、Noriyasu Haginoya、Kenji Yoshikawa、Yumiko Isobe、Taketoshi Furugohri、Hideyuki Kanno

  DOI：10.1016/j.bmcl.2007.05.068

  日期：2007.8

  This paper describes the synthesis of orally available potent fXa inhibitors 2 and 3 by modification of tile piperazine part of lead compound 1. Carbonyl derivative 3 showed potent fXa activity but not sulfonyl derivative 2. Among the compounds synthesized, cyclohexane derivatives 3g and 3h and cycloheptane derivative 3j had potent anticoagulant activity as well as anti-fXa activity. Synthetic Study of the optical isomers of 3g demonstrated that (-)-3g had more potent activity.(c) 2007 Elsevier Ltd. All rights reserved.
• US7192968B2
  申请人：——

  公开号：US7192968B2

  公开（公告）日：2007-03-20
• US7935824B2
  申请人：——

  公开号：US7935824B2

  公开（公告）日：2011-05-03