3-(2-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy)acetamido)-4’-fluorobiphenyl-4-carboxylic acid | 1103927-62-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy)acetamido)-4’-fluorobiphenyl-4-carboxylic acid
• 英文别名: 3-(2-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy)acetamido)-4'-fluorobiphenyl-4-carboxylic acid；2-[[2-[2-(4-Benzhydrylpiperazin-1-yl)-2-oxoethoxy]acetyl]amino]-4-(4-fluorophenyl)benzoic acid
• CAS: 1103927-62-3
• 化学式: C₃₄H₃₂FN₃O₅
• 分子量: 581.644
• InChiKey: SXOPLZUGNQVUFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  43
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  99.2
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR
  申请人：Miyata Toshio

  公开号：US20090124620A1

  公开（公告）日：2009-05-14

  The present invention relates to an inhibitor of plasminogen activator inhibitor-1. The present invention further relates to a pharmaceutical composition that has an inhibitory action on PAI-1 activity and is useful in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity. Furthermore, the present invention relates to a novel compound having PAI-1 inhibitory activity represented by the following general formula (I), and a salt thereof. Each symbol is defined as those in the specification.

  本发明涉及一种抑制纤溶酶原激活物抑制剂-1的抑制剂。本发明进一步涉及一种对PAI-1活性具有抑制作用的药物组合物，可用于预防和治疗与PAI-1活性相关的各种疾病的发生。此外，本发明涉及一种具有PAI-1抑制活性的新化合物，其由以下一般式（I）表示，并且其盐。每个符号的定义如规范中所述。
• NOVEL USE FOR PAI-1 INHIBITOR
  申请人：Renascience Co., Ltd.

  公开号：EP2990057A1

  公开（公告）日：2016-03-02

  Provided is a novel use of a plasminogen activator inhibitor-1 inhibitor (PAI-1 inhibitor) that is used as an active ingredient of an agent for controlling a tumor stem cell, an agent for enhancing the antitumor effect of an antitumor agent, an agent for tumor chemotherapy, a stem-cell protecting drug, or a hematopoietic disorder improving agent.

  本发明提供了一种纤溶酶原激活物抑制剂-1 抑制剂（PAI-1 抑制剂）的新用途，该抑制剂可用作控制肿瘤干细胞的药物、增强抗肿瘤药物抗肿瘤效果的药物、肿瘤化疗药物、干细胞保护药物或改善造血障碍药物的活性成分。
• Use for PAI-1 inhibitor
  申请人：RENASCIENCE CO., LTD.

  公开号：US10092537B2

  公开（公告）日：2018-10-09

  Provided is a novel use of a plasminogen activator inhibitor-1 inhibitor (PAI-1 inhibitor) that is used as an active ingredient of an agent for controlling a tumor stem cell, an agent for enhancing the antitumor effect of an antitumor agent, an agent for tumor chemotherapy, a stem-cell protecting drug, or a hematopoietic disorder improving agent.

  本发明提供了一种纤溶酶原激活物抑制剂-1 抑制剂（PAI-1 抑制剂）的新用途，该抑制剂可用作控制肿瘤干细胞的药物、增强抗肿瘤药物抗肿瘤效果的药物、肿瘤化疗药物、干细胞保护药物或改善造血障碍药物的活性成分。
• Secreted and transmembrane polypeptides and nucleic acids encoding the same
  申请人：Genentech, Inc.

  公开号：US20030044841A1

  公开（公告）日：2003-03-06

  The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

  本发明涉及新型多肽和编码这些多肽的核酸分子。 本发明还提供了包含这些核酸序列的载体和宿主细胞、包含与异源多肽序列融合的本发明多肽的嵌合多肽分子、与本发明多肽结合的抗体以及生产本发明多肽的方法。
• SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME
  申请人：Baker P. Kevin

  公开号：US20050043520A1

  公开（公告）日：2005-02-24

  The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

  本发明涉及新型多肽和编码这些多肽的核酸分子。本发明还提供了包含这些核酸序列的载体和宿主细胞、包含与异源多肽序列融合的本发明多肽的嵌合多肽分子、与本发明多肽结合的抗体以及生产本发明多肽的方法。