(4-fluorophenyl)phenylmethanone oxime | 362-99-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-fluorophenyl)phenylmethanone oxime
• 英文别名: 4-fluoro-benzophenone-seqtrans-oxime；4-Fluor-benzophenon-seqtrans-oxim；(NE)-N-[(4-fluorophenyl)-phenylmethylidene]hydroxylamine
• CAS: 362-99-2
• 化学式: C₁₃H₁₀FNO
• 分子量: 215.227
• InChiKey: VQCPGTQZPMEMKN-FYWRMAATSA-N

物化性质

• 熔点：
  135 °C
• 沸点：
  334.4±34.0 °C(Predicted)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4-fluorophenyl)phenylmethanone oxime 在 乙醚 、 五氯化磷 作用下， 生成 N-(4-氟苯基)苯甲酰胺
  参考文献：
  名称：

  Bergmann; Hoffmann; Meyer, Journal fur praktische Chemie (Leipzig 1954), 1932, vol. <2> 135, p. 245,252

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氟二苯甲酮 生成 (4-fluorophenyl)phenylmethanone oxime
  参考文献：
  名称：

  Bergmann; Hoffmann; Meyer, Journal fur praktische Chemie (Leipzig 1954), 1932, vol. <2> 135, p. 245,252

  摘要：

  DOI：

文献信息

• Method of making patterns
  申请人：CIBA-GEIGY AG

  公开号：EP0326516A2

  公开（公告）日：1989-08-02

  A method of making a metallic pattern on a substrate having a surface comprising bare metal in predetermined areas and metal coated by a resist in remaining areas comprises (i) protecting the bare metal by electrodepositing thereon a heat-curable polymeric film having (a) a group which is reactive with an isocyanate group and (b) a blocked isocyanate group, (ii) heating the electrodeposited polymeric film to render it resistant to a solvent with which the resist is removable, (iii) removing the resist from said remaining areas using a solvent which does not remove the electrodeposited polymeric film, thereby exposing metal in said remaining areas, and (iv) etching the metal exposed in step (iii) using an etchant which does not remove the electrodeposited polymeric film, thereby leaving a metallic pattern protected by the electrodeposited polymeric film, which can be removed subsequently using a solvent therefor. The method is useful in the production of printed circuits.

  一种在基底上制作金属图案的方法，该基底的表面包括预定区域的裸金属和剩余区域的抗蚀剂涂层金属，该方法包括 (i) 在裸金属上电沉积一层热固化聚合膜以保护裸金属，该聚合膜具有 (a) 与异氰酸酯基团反应的基团和 (b) 被阻断的异氰酸酯基团、 (ii) 加热电沉积的聚合物薄膜，使其能够耐受可去除抗蚀剂的溶剂、 (iii) 使用不去除电沉积聚合物薄膜的溶剂去除所述剩余区域的抗蚀剂，从而在所述剩余区域暴露金属，以及 (iv) 使用不去除电沉积聚合物薄膜的蚀刻剂蚀刻步骤(iii)中暴露的金属，从而留下受电沉积聚合物薄膜保护的金属图案，随后可使用溶剂将其去除。 该方法适用于印刷电路的生产。
• Steroid derivatives for the treatment of prostatic hypertrophy, their preparation and uses
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0567271A2

  公开（公告）日：1993-10-27

  Compounds of formula (I): [wherein : R1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl ; R2 is: aryl-substituted alkyl, aromatic heterocyclic-substituted alkyl or diarylamino; and R3 is carboxy or a group of formula -CONHS02 R4 wherein R4 is alkyl] ; and pharmaceutically acceptable salts and esters thereof have valuable 5α-reductase inhibitory activity and can thus be used for the treatment and prophylaxis of, inter alia, prostatic hypertrophy as well as other disorders arising from excess levels of 5α-dihydro-testosterone.

  式(I)化合物： [其中 ：R1 是氢、烷基、芳基取代的烷基或芳香杂环取代的烷基；R2 是：芳基取代的烷基、芳香杂环取代的烷基或二芳基氨基；以及 R3 是羧基或式 -CONHS02 R4 的基团，其中 R4 是烷基]；及其药学上可接受的盐类和酯类具有重要的 5α 还原酶抑制活性，因此可用于治疗和预防前列腺肥大以及因 5α 二氢睾酮水平过高而引起的其他疾病。
• Compounds suitable for use as intermediates in the preparation of Androst-3,5-dien-3-carboxy derivatives
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0725074A2

  公开（公告）日：1996-08-07

  A compound of formula (IV) and a process for the preparation of a compound of the following formula: in which R10 is a hydroxy group, a group -OR5, in which R5 is a carboxy protecting group, a group -NR1R2, in which R1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl and R2 is aryl-substituted alkyl, aromatic heterocyclic-substituted alkyl or diarylamino, or a group -NRR', in which R and R' are hydrogen or alkyl.

  式(IV)化合物 以及制备下式化合物的工艺： 其中 R10 是羟基、基团-OR5（其中 R5 是羧基保护基）、基团-NR1R2（其中 R1 是氢、烷基、芳基取代的烷基或芳香杂环取代的烷基，R2 是芳基取代的烷基、芳香杂环取代的烷基或二芳基氨基）或基团-NRR'（其中 R 和 R' 是氢或烷基）。
• Massolini; Carmellino; Baruffini, Il Farmaco, 1994, vol. 49, # 11, p. 747 - 749
  作者：Massolini、Carmellino、Baruffini

  DOI：——

  日期：——
• Massolini; Carmellino; Baruffini, Farmaco, Edizione Scientifica, 1987, vol. 42, # 2, p. 117 - 124
  作者：Massolini、Carmellino、Baruffini

  DOI：——

  日期：——