(6R,7R)-3-acetoxymethyl-7-[2-(2-methyl-quinolin-4-ylamino)-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 874980-00-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (6R,7R)-3-acetoxymethyl-7-[2-(2-methyl-quinolin-4-ylamino)-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 英文别名: (6R,7R)-3-(acetyloxymethyl)-7-[[2-[(2-methylquinolin-4-yl)amino]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• CAS: 874980-00-4
• 化学式: C₂₂H₂₂N₄O₆S
• 分子量: 470.506
• InChiKey: HHVQKNAAQGWFHQ-WIYYLYMNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  163
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Hybrid molecules QA, wherein Q is an aminoquinoline and a is an antibiotic or a resistance enzyme inhibitor, their synthesis and their uses as antibacterial agent
  申请人：Sanchez Muriel

  公开号：US20060025327A1

  公开（公告）日：2006-02-02

  Aminoquinoline-antibiotic hybrid compounds in the form of hybrid molecules QA, wherein Q is an aminoquinoline and A is an antibiotic or a resistance enzyme inhibitor, their synthesis and their uses as antibacterial agent. This compound is defined by the general formula (I): Q-(Y 1 ) p —(U) p′ —(Y 2 ) p″ -A  (I) in which Q represents an aminoquinoline, (Y 1 ) p —(U) p′ —(Y 2 ) p″ — is an optional spacer arm and A is an antibiotic, one of its derivatives or precursors, or a resistance enzyme inhibitor. The invention unexpectedly enables the activity of the antibiotic to be improved.

  氨基喹啉-抗生素混合物化合物以混合分子QA的形式存在，其中Q是氨基喹啉，A是抗生素或耐药酶抑制剂，它们的合成及用途作为抗菌剂。该化合物由通用公式(I)定义：Q-(Y1)p—(U)p′—(Y2)p″-A  (I)其中Q代表氨基喹啉，(Y1)p—(U)p′—(Y2)p″—为可选的间隔臂，A是抗生素、其衍生物或前体之一，或耐药酶抑制剂。该发明意外地能够改善抗生素的活性。
• Steroid sparing agents and methods of using same
  申请人：Lieberburg Ivan

  公开号：US20060004019A1

  公开（公告）日：2006-01-05

  This invention relates generally to methods of treatment of inflammatory bowel diseases (IBD), asthma, multiple schlerosis (MS), rheumatoid arthritis (RA), graft vs. host disease (GVHD), host vs. graft disease, and various spondyloarthropathies, comprising administering a steroid sparing immunoglobulin or small molecule composition to a patient in need thereof. The invention also relates generally to combination therapies for the treatment of these conditions.

  本发明涉及治疗炎症性肠病(IBD)、哮喘、多发性硬化症(MS)、类风湿性关节炎(RA)、移植物抗宿主病(GVHD)、宿主抗移植物病以及各种脊柱关节病的方法，包括向需要治疗的患者投予一种节省类固醇的免疫球蛋白或小分子组合物。本发明还涉及治疗这些疾病的联合疗法。
• Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents
  申请人：Sanchez Muriel

  公开号：US20070060558A1

  公开（公告）日：2007-03-15

  The invention concerns an aminoquinoline-antibiotic hybrid compound of general formula (I): Q—(Y 1 ) p —(U) p —(Y 2 ) p -A: wherein Q represents an aminoquinoline, (Y 1 ) p (U) p —(Y 2 ) p″ is an optional spacer and A is an antibiotic residue. The invention enables the antibiotic residue activity to be unexpectedly enhanced.

  本发明涉及一种氨基喹啉-抗生素杂合物，其一般式为(I)：Q—(Y1)p—(U)p—(Y2)p-A，其中Q代表氨基喹啉，(Y1)p(U)p—(Y2)p″是可选的间隔基，A为抗生素残基。本发明使得抗生素残基的活性得到了意外的增强。
• US7101855B2
  申请人：——

  公开号：US7101855B2

  公开（公告）日：2006-09-05