3-Hydroxy-N-methyl-2-phenyl-propionamide | 96392-47-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Hydroxy-N-methyl-2-phenyl-propionamide
• 英文别名: 3-hydroxy-N-methyl-2-phenylpropanamide
• CAS: 96392-47-1
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: HRTLVGHRYWBEIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Method for the Preparation of Peptide-Oligonucleotide Conjugates
  申请人：Katzhendler Jehoshua

  公开号：US20080221303A1

  公开（公告）日：2008-09-11

  The present invention relates to the synthesis of peptide-oligonucleotide conjugates (POC). More specifically, the invention relates to a novel method for the preparation of peptide-oligonucleotide conjugates, which can be conducted under mild conditions on solid support, can be performed manually or by a synthesizer, can be used to synthesize alternating sequences of peptides and oligonucleotides, and is applicable to the synthesis of a wide variety of peptide-oligonucleotide conjugates constructed from alternate peptide and oligonucleotide blocks.

  本发明涉及肽-寡核苷酸共轭物（POC）的合成。更具体地说，本发明涉及一种新颖的肽-寡核苷酸共轭物的制备方法，可以在固相支持下在温和条件下进行，可以手动或通过合成器进行，可以用于合成肽和寡核苷酸的交替序列，并适用于从交替肽和寡核苷酸块构建的各种肽-寡核苷酸共轭物的合成。
• Hepatitis C assay
  申请人：ABBOTT LABORATORIES

  公开号：EP0445423A2

  公开（公告）日：1991-09-11

  The present invention provides an improved assay for detecting the presence of an antibody to an HCV antigen in a sample by contacting the sample with polypeptide containing at least one epitope of an HCV antigen. Preferred assay formats include a confirmatory assay, a combination assay, a synthetic polypeptide-based assay, an immunodot assay, and a competition assay.

  本发明提供了一种改进的检测方法，通过将样品与含有至少一种 HCV 抗原表位的多肽接触，检测样品中是否存在 HCV 抗原抗体。首选的检测方法包括确证检测法、组合检测法、基于合成多肽的检测法、免疫点检测法和竞争检测法。
• Motilin-like polypeptides that inhibit gastrointestinal motor activity
  申请人：Ohmeda Pharmaceutical Products Division Inc.

  公开号：EP0647656A1

  公开（公告）日：1995-04-12

  This invention pertains to polypeptides having gastrointestinal motor inhibitory activity represented by the formula: including optically active isomeric forms and the pharmaceutically acceptable acid addition salts thereof wherein A is the L-stereoisomer of a lipophilic aliphatic or alicyclic amino acid; B is selected from the group consisting of L and D aromatic, heteroaromatic, lipophilic aliphatic, and alicyclic amino acids; D is the L-stereoisomer of a lipophilic aliphatic or alicyclic amino acid; E is the L-stereoisomer of an aromatic, aliphatic, or alicyclic amino acid; F is the L-stereoisomer of an aromatic or heteroaromatic amino acid; G is glycine or D-alanine; H is L-glutamic acid or L-glutamine; I is L-glutamine, L-glutamic acid, or L-alanine; J is a direct bond between I and group -NH- or is selected from the group consisting of Z, Z-Leu, Z-Leu-Gln, Z-Leu-Gln-Glu, Z-Leu-Gln-Glu-Lys, Z-Leu-Gln-Glu-Lys-Glu, Z-Leu-Gln-Glu-Lys-Glu-Arg, Z-Leu-Gln-Glu-Lys-Glu-Arg-Asn, Z-Leu-Gln-Glu-Lys-Glu-Arg-Asn-Lys, and Z-Leu-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly, wherein Z is selected from the group consisting of arginine, D-arginine, D-homoarginine, D-lysine, D-ornithine, D-2,4-diaminobutyric acid, D-glutamine, D-asparagine, and D-atanine; R₁ and R₂ are independently hydrogen or lower-alkyl; R₃ is selected from the group consisting of lower-alkyl, cycloalkyl, substituted and unsubstituted aryl, and heteroaryl, wherein the aryl group may be substituted with one or more substituents selected from the group consisting of halogen, hydroxy, and lower-alkoxy; R₄ is selected from the group consisting of -CH₂CONH₂, aminoalkyl groups containing from 1 to 3 carbon atoms, and guanidinoalkyl groups containing 2 or 3 carbon atoms; R₅ is -COOH or -CONH₂; and the symbol * represents an asymmetric carbon atom which may be in the D or L configuration, and each lower-alkyl group contains from 1 to 4 carbon atoms, with the proviso that R₄ is -CH₂CONH₂ only when J is Z-Leu or Z-Leu-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly.

  本发明涉及具有胃肠道运动抑制活性的多肽，由式表示： 包括光学活性异构体形式及其药学上可接受的酸加成盐 其中 A 是亲脂性脂肪族或脂环族氨基酸的 L-立体异构体；B 选自 L 和 D 芳族、杂芳族、亲脂性脂肪族和脂环族氨基酸组成的组；D 是亲脂脂肪族或脂环族氨基酸的 L-立体异构体； E 是芳香族、脂肪族或脂环族氨基酸的 L-立体异构体； F 是芳香族或杂芳香族氨基酸的 L-立体异构体； G 是甘氨酸或 D-丙氨酸；H 是 L-谷氨酸或 L-谷氨酰胺；I 是 L-谷氨酰胺、L-谷氨酸或 L-丙氨酸；和 Z-Leu-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly，其中 Z 选自由精氨酸、D-精氨酸、D-高精氨酸、D-赖氨酸、D-鸟氨酸、D-2,4-二氨基丁酸、D-谷氨酰胺、D-天冬酰胺和 D-天冬氨酸组成的组；R₁ 和 R₂ 独立地为氢或低级烷基；R₃ 选自由低级烷基、环烷基、取代和未取代的芳基和杂芳基组成的组，其中芳基可被一个或多个选自由卤素、羟基和低级烷氧基组成的组的取代基取代；R₄ 选自由 -CH₂CONH₂、含 1 至 3 个碳原子的氨基烷基和含 2 或 3 个碳原子的胍基所组成的组； R₅ 是 -COOH 或 -CONH₂；符号 * 代表不对称碳原子，可以是 D 或 L 构型，每个低级烷基含有 1 至 4 个碳原子，但只有当 J 为 Z-Leu 或 Z-Leu-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly 时，R₄ 才是 -CH₂CONH₂。
• Cyclic motilin-like polypeptides with gastrointestinal motor stimulating activity
  申请人：Ohmeda Pharmaceutical Products Division Inc.

  公开号：EP0807639A2

  公开（公告）日：1997-11-19

  This invention pertains to cyclic polypeptides having gastrointestinal motor stimulating activity which may be represented by formula (1): including optically active isomeric forms and the pharmaceutically acceptable acid addition salts thereof, wherein groups A and D are linked to from a cyclic structure; and R1 is lower alkyl; R2 is hydrogen or lower alkyl; R3 is hydrogen or lower alkyl; R4 is phenyl or substituted phenyl, wherein the phenyl group may be substituted with one or more substituents selected from the group consisting of halogen, hydroxy, and lower alkoxy; R5 is -OH or -NH2; A is selected from the group consisting of L-glutamic acid, L-aspartic acid, L-lysine, L-ornithine, and L-2,4-diaminobutyric acid; B is L-alanine or L-glutamine; C is L-arginine or D-arginine; D is selected from the group consisting of L-lysine, L-ornithine, L-2,4-diaminobutyric acid, L-glutamic acid, and L-aspartic acid; E is a direct bond between group D and group R5 or is L-lysine or D-lysine; m is 0 or 1; the symbol * represents an asymmetric carbon atom which may be in the D or L configuration, with the proviso that: (a) when A is L-glutamic acid or L-aspartic acid, D is L-lysine, L-ornithine, or L-2,4-diaminobutyric acid; and (b) when A is L-lysine, L-ornithine, or L-2,4-diaminobutyric acid, D is L-glutamic acid or L-aspartic acid. This invention also pertains to methods for using the novel cyclic polypeptides.

  本发明涉及具有胃肠道运动刺激活性的环状多肽，可由式（1）表示： 包括光学活性异构体形式及其药学上可接受的酸加成盐，其中基团A和D由环状结构连接；R1为低级烷基；R2为氢或低级烷基；R3为氢或低级烷基；R4为苯基或取代苯基，其中苯基可被一个或多个选自卤素、羟基和低级烷氧基的取代基取代；R5为-OH或-NH2；A 选自 L-谷氨酸、L-天冬氨酸、L-赖氨酸、L-鸟氨酸和 L-2,4-二氨基丁酸组成的组；B 是 L-丙氨酸或 L-谷氨酰胺；C 是 L-精氨酸或 D-精氨酸；D 选自 L-赖氨酸、L-鸟氨酸、L-2,4-二氨基丁酸、L-谷氨酸和 L-天冬氨酸组成的组；E 是 D 组和 R5 组之间的直接键，或者是 L-赖氨酸或 D-赖氨酸；m 是 0 或 1；符号 * 代表不对称碳原子，可以是 D 或 L 构型，但有以下限制条件(a) 当 A 为 L-谷氨酸或 L-天冬氨酸时，D 为 L-赖氨酸、L-鸟氨酸或 L-2,4-二氨基丁酸；以及 (b) 当 A 为 L-赖氨酸、L-鸟氨酸或 L-2,4-二氨基丁酸时，D 为 L-谷氨酸或 L-天冬氨酸。本发明还涉及使用新型环状多肽的方法。
• HEPATITIS C ASSAY
  申请人：ABBOTT LABORATORIES

  公开号：EP0642666B1

  公开（公告）日：2000-04-12