isoamyldibutylammonium bromide | 41781-51-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: isoamyldibutylammonium bromide
• 英文别名: N,N-dibutyl-3-methyl-butylamine；dibutyl-isopentyl-amine；Isoamyldibutylamine；N,N-dibutyl-3-methylbutan-1-amine
• CAS: 41781-51-5
• 化学式: C₁₃H₂₉N
• 分子量: 199.38
• InChiKey: ISKSBOLDFHAMEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  异戊基碘 、 isoamyldibutylammonium bromide 在 丁酮 作用下， 生成 dibutyl-diisopentyl-ammonium; iodide
  参考文献：
  名称：

  The Competitive Formation of Different Olefins from Quaternary Amines

  摘要：

  DOI：

  10.1021/ja01122a067
• 作为产物：
  描述：

  异戊基碘 、 二正丁胺 在 sodium carbonate 、 甘油 作用下， 生成 isoamyldibutylammonium bromide
  参考文献：
  名称：

  The Competitive Formation of Different Olefins from Quaternary Amines

  摘要：

  DOI：

  10.1021/ja01122a067

文献信息

• Eight-arm polyethylene glycol derivative, production method therefor, and modified bio-related substance thereof
  申请人：Xiamen Sinopeg Biotech Co., Ltd.

  公开号：US10660969B2

  公开（公告）日：2020-05-26

  Disclosed are an 8-arm polyethylene glycol (PEG) derivative (formula 1), manufacturing method and modified bio-related substance thereby, wherein a tetravalent group U and four trivalent groups Ec form a highly symmetric octavalent central structure CORE0 together, Lc connects the octavalent center to eight PEG arms having polydiversity or monodiversity and having n1-n8 as the degrees of polymerization thereof. The terminal of one PEG chain is connected to at least one functional group F (k≥1), and said PEG chain and F can be directly connected (g=0) or connected with a divalent linking group L0 connected with a terminal branched group G (g=1) therebetween. The latter provides more reacting sites to combine more pharmaceutical molecules, thereby increasing the drug loading capacity. The near-center symmetric structure of the derivative allows more precise control over the molecular weight during large-scale production, thereby facilitating acquisition of a product having a narrower molecular weight distribution. A bio-related substance modified thereby has a more uniform and controllable performance.

  本发明公开了一种 8 臂聚乙二醇（PEG）衍生物（式 1）、其制造方法和改性生物相关物质，其中一个四价基团 U 和四个三价基团 Ec 共同形成一个高度对称的八价中心结构 CORE0，Lc 将八价中心连接到八个 PEG 臂上，这些 PEG 臂具有多元性或单元性，其聚合度为 n1-n8。一条 PEG 链的末端与至少一个官能团 F（k≥1）相连，所述 PEG 链和 F 可以直接相连（g=0），也可以通过二价连接基 L0 与末端支化基 G（g=1）相连。后者提供了更多的反应位点，可结合更多的药物分子，从而提高药物负载能力。衍生物的近中心对称结构可以在大规模生产过程中更精确地控制分子量，从而有利于获得分子量分布更窄的产品。由此改性的生物相关物质具有更均匀、更可控的性能。
• ——
  作者：L. S. Aladko、Yu. A. Dyadin、T. V. Mikina

  DOI：10.1023/a:1015479214335

  日期：——

  In the system i-Am2Bu2NBr-H2O, along with the known compound i-Am2Bu2NBr.38H(2)O, three new clathrate hydrates were revealed: i-Am2Bu2NBr.32H(2)O, i-Am2Bu2NBr.26H(2)O, and i-Am2Bu2NBr.24H(2)O. Crystals of all the hydrates were isolated, and their compositions and melting points were determined.
• PH-Responsive Nanoparticles for Treating Cancer
  申请人：United States Government as represented by the Department of Veterans Affairs

  公开号：US20220378711A1

  公开（公告）日：2022-12-01

  Disclosed are nanoparticles comprising a polymer carrier formed from a poly(ethylene glycol) and a poly(carbonate) copolymer which encapsulates a cargo entity such as an ERK inhibitor and/or chemotherapeutic agent. Therapeutic uses of the nanoparticles are also described, including methods of treating a cancer such as pancreatic cancer.
• US4306056A
  申请人：——

  公开号：US4306056A

  公开（公告）日：1981-12-15
• The Competitive Formation of Different Olefins from Quaternary Amines
  作者：Peter A. S. Smith、Simon Frank

  DOI：10.1021/ja01122a067

  日期：1952.1