| 1382487-16-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• CAS: 1382487-16-2
• 化学式: C₂₆H₃₂O₄
• 分子量: 408.538
• InChiKey: UZTOGQPGCIYENS-ZONVZMRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.35
• 重原子数：
  30.0
• 可旋转键数：
  3.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  55.76
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  2-萘酚 、 (-)-menthyl 2-oxocyclopentane-1-carboxylate 在 二叔丁基过氧化物 、 iron(III) chloride hexahydrate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 2.0h， 以37%的产率得到
  参考文献：
  名称：

  Ligand-Controlled Iron-Catalyzed Coupling of α-Substituted β-Ketoesters with Phenols

  摘要：

  A chemo-, regio-, and stereoselective FeCl3/1,10-phenanthroline-catalyzed cross dehydrogenative coupling (CDC) reaction between phenols and alpha-substituted beta-ketoesters was developed. The reaction creates a new quaternary carbon center within a polycyclic hemiacetal or polycyclic spirolactone architecture. The applicability of the new method to the synthesis of natural products was demonstrated by a possible biomimetic synthesis of the lachnanthospirone core.

  DOI：

  10.1021/ol301297k

文献信息

• Iron Phosphate Catalyzed Asymmetric Cross-Dehydrogenative Coupling of 2-Naphthols with β-Ketoesters
  作者：Sachin Narute、Doron Pappo

  DOI：10.1021/acs.orglett.7b01152

  日期：2017.6.2

  Chiral iron phosphate complexes were successfully exploited for asymmetric cross-dehydrogenative coupling reactions between 2-naphthols and beta-ketoester derivatives. On the basis of kinetic studies, it is suggested that iron monophosphate complexes constitute the active catalysts that induce stereoselectivity during the carboncarbon bond-formation step.