4-(4-((4'-chloro-1,1'-biphenyl-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-((2-oxo-1,2,3,4-tetrahydroquinolin-5-yl)oxy)benzamide | 1228938-83-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-((4'-chloro-1,1'-biphenyl-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-((2-oxo-1,2,3,4-tetrahydroquinolin-5-yl)oxy)benzamide
• 英文别名: 4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-[(2-oxo-3,4-dihydro-1H-quinolin-5-yl)oxy]benzamide
• CAS: 1228938-83-7
• 化学式: C₄₅H₄₅ClN₆O₈S
• 分子量: 865.407
• InChiKey: JTHPVBULJQVKHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  61
• 可旋转键数：
  12
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  184
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
  申请人：Bruncko Milan

  公开号：US20100160322A1

  公开（公告）日：2010-06-24

  Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

  揭示了抑制抗凋亡Bcl-2蛋白活性的化合物，含有这些化合物的组合物以及治疗在其中表达抗凋亡Bcl-2蛋白的疾病的方法。
• CRACK RESISTANT MEMBER
  申请人：Daicel Corporation

  公开号：EP3915614A1

  公开（公告）日：2021-12-01

  A crack resistant member including a member body, a first region (33) that is a hollow space provided in the member body to open to a surface of the member body and is configured to dispose a driving part that outputs a pressing force in an extension direction of the space, and a coupling portion that is configured to mechanically couple to the driving part and is formed on an inner wall surface of the first region (33), in which at least the coupling portion is formed from a resin material having a flexural modulus of 2600 MPa or greater as measured in accordance with ISO 178.

  一种抗裂构件，包括构件本体、第一区域（33），第一区域是构件本体内设置的中空空间，开口于构件本体的表面，并被配置为放置一个驱动部件，该驱动部件在空间的延伸方向上输出压紧力；以及耦合部分，耦合部分被配置为与驱动部件机械耦合，并形成于第一区域（33）的内壁表面上，其中至少耦合部分是由一种树脂材料形成的，根据 ISO 178 测量，该树脂材料的弯曲模量大于等于 2600 兆帕。
• POLYAMIDE MOULDING COMPOUNDS AND THEIR APPLICATION
  申请人：PFLEGHAR Mark

  公开号：US20140066561A1

  公开（公告）日：2014-03-06

  This invention describes a thermoplastic moulding compound, specifically a polyamide moulding compound, consisting of: (A) 20-88% by weight thermoplastic synthetic, preferably polyamide; (B) 10-70% by weight fibre-shaped aggregates; (B1) 10-70% by weight glass fibres that consist primarily of silicon dioxide, aluminium oxide, and magnesium oxide; (B2) 0-20% by weight glass fibres that differ from the fibres in components (B1); (B3) 0-20% by weight additional fibre-shaped aggregates that differ from the fibres in components (B1) and (B2), are not based on glass, and are selected from the following group: carbon fibres, graphite fibres, aramide fibres, nanotubes; (C) 2-40% by weight particulate filler material; (D) 0-2% by weight additives; whereby the sum of (A) through (D) equals 100% weight.
• US8557983B2
  申请人：——

  公开号：US8557983B2

  公开（公告）日：2013-10-15
• US9029404B2
  申请人：——

  公开号：US9029404B2

  公开（公告）日：2015-05-12