N-[2,6-di(propan-2-yl)phenyl]-3,3-dimethylbutan-2-imine | 215715-83-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2,6-di(propan-2-yl)phenyl]-3,3-dimethylbutan-2-imine
• CAS: 215715-83-6
• 化学式: C₁₈H₂₉N
• 分子量: 259.435
• InChiKey: ZXBIHXACSYPIHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-[2,6-di(propan-2-yl)phenyl]-3,3-dimethylbutan-2-imine 在 lithium aluminium tetrahydride 、 正丁基锂 、 四甲基乙二胺 作用下， 以 正己烷 为溶剂， 生成 Bis[2-[2,6-di(propan-2-yl)phenyl]imino-3,3-dimethylbutyl]phosphaniumylboranuide
  参考文献：
  名称：

  Metal-Free σ-Bond Metathesis in Ammonia Activation by a Diazadiphosphapentalene

  摘要：

  A diazadiphosphapentalene derivative 5 featuring a bent geometry with two phosphorus atoms at the bridgehead has been synthesized. Under mild conditions, compound 5 readily activated ammonia to afford 1-aza-2,3-diphospholene derivative 6 bearing an enamine group. The reaction is therefore viewed as a formal s-bond metathesis between an N-H bond of ammonia and an endocyclic P-N bond of 5. Details of the reaction mechanism for ammonia activation as well as subsequent isomerization were explored by density functional theory calculations.

  DOI：

  10.1021/ja509963m

文献信息

• Lewis acid-catalyzed hydrogenation: B(C6F5)3-mediated reduction of imines and nitriles with H2
  作者：Preston A. Chase、Titel Jurca、Douglas W. Stephan

  DOI：10.1039/b718598g

  日期：——

  The Lewis acid B(C(6)F(5))(3) has been found to be an efficient catalyst for the direct hydrogenation of imines and the reductive ring-opening of aziridines with H(2) under mild conditions; addition of a bulky phosphine allows for the reduction of protected nitriles.

  路易斯酸B（C（6）F（5））（3）被发现是在温和条件下直接加成亚胺和用H（2）还原氮丙啶的开环的有效催化剂。添加大体积的膦可以减少受保护的腈。
• Chemistry of BDI*M(2+) complexes (M = Mg, Zn) and their role in lactide polymerization where BDI* is the anion derived from methylenebis(C-tBu, N-2,6-diisopropylphenyl)imine BDI*H
  作者：Carla N. Ayala、Malcolm H. Chisholm、Judith C. Gallucci、Clemens Krempner

  DOI：10.1039/b910669c

  日期：——

  with either 1 or 3 in hydrocarbon and ether solvents to give BDI*Mg((n)Bu)THF, 4, and BDI*ZnEt, 5, which have been structurally characterized. M(N(SiMe(3))(2))(2) compounds where M = Mg, Zn or Ca failed to react with either 1 or 3 in hydrocarbon solvents. The reactions between ZnCl(2) and 2 yield BDI*ZnCl, 6, and a further reaction with LiNMe(2) yields BDI*ZnNMe(2), 7. The compounds 5 and 6 are shown

  庞大的二亚胺CH（2）C（（t）Bu）N-2,6-Pr（i）（2）C（6）H（3）}（2）BDI * H显示存在于在NMR时标上缓慢互变的两个异构体反式-反式1a和顺式-反式1b。在己烷中用（n）BuLi处理二亚胺的过程缓慢进行，得到β-二酮基锂LiBDI *，2，水解后生成BDI * H的乙亚胺互变异构体，已通过X射线研究了三种旋转异构体3a对其进行了表征。 ，3b和3c。二烷基金属化合物（M = Mg，R = Bu； M = Zn，R = Et）在烃和醚溶剂中与1或3反应生成BDI * Mg（（n）Bu）THF，4和BDI * ZnEt，参照图5，已经对其进行了结构表征。M（N（SiMe（3））（2））（2）的化合物，其中M = Mg，Zn或Ca在烃类溶剂中无法与1或3反应。ZnCl（2）和2之间的反应产生BDI * ZnCl，6，然后与LiNMe（2）进一步反应，生成BDI * Z