4,4,5,5,6,6,6-heptafluoro-1-(2-naphthyl)-1,3-hexanedione | 77459-91-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4,5,5,6,6,6-heptafluoro-1-(2-naphthyl)-1,3-hexanedione
• 英文别名: 4,4,5,5,6,6,6-Heptafluoro-1-(2-naphthyl)hexane-1,3-dione；4,4,5,5,6,6,6-heptafluoro-1-naphthalen-2-ylhexane-1,3-dione
• CAS: 77459-91-7
• 化学式: C₁₆H₉F₇O₂
• 分子量: 366.235
• InChiKey: ZTQDJPADJMYCGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  europium(III) acetate hydrate 、 4,4,5,5,6,6,6-heptafluoro-1-(2-naphthyl)-1,3-hexanedione 以 甲醇 、 乙醇 为溶剂， 以70%的产率得到tris(6,6,7,7,8,8,8-heptafluoro-1-(2-naphthyl)-1,3-hexanedionato)europium(III)
  参考文献：
  名称：

  Remarkable chiral and luminescent properties of novel Yb(III) and Eu(III) complexes containing BINAPO ligand

  摘要：

  Lanthanide complexes are of great importance for their prospective applications in wide range of science and technology. Chiral lanthanide complexes can constitute stereo-discriminating probes in biological media, owing to the luminescent properties of the rare-earth ions. Sensitized emission with narrow bandwidth, having fast radiation rate and high emission quantum efficiency are the main perspective for synthesizing the complexes. Attention has been given on remarkable chirality with high dissymmetry factors (g = Delta epsilon(ext)/epsilon(max)) of the complexes. For this purpose, beta-diketonato ligands with chiral BINAPO (1,1'-binapthyl phosphine oxide) ligand were chosen to achieve the goal. The complexes [Ln(TFN)(3)-(S-BINAPO)](TFN = 4,4,4- trifluoro-1(2-napthyl)-1,3-butanedione), [Ln(HFT)(3)(S-BINAPO)] (HFT = 4,4,5,5,6,6,6-heptafluoro-1-(2-thienyl)-1,3-hexanedione) and [Ln(HFA)(3)(S-BINAPO)](hfa = hexafluoroacetylacetonate) (where Ln = Yb, Eu) were synthesized. The complex, [Eu(TFN)(3)(S-BINAPO)] gives strong red emission at 615 nm with narrow emission band (< 10 nm) when excited by 465 nm light with quantum efficiency 86%. The dissymmetry factors (g = Delta epsilon(ext)/epsilon(max)) corresponding to the F-7(1) -> D-5(0) transition at 590 nm is 0.091 for [Eu(TFN)(3)(S-BINAPO)] and for [Yb(hfa)(3)(S-BINAPO)](hfa = hexafluoroacetylacetonate) corresponding to the F-2(7/2) -> F-2(5/2) transitions is 0.12, are among the largest values for both Eu and Yb complexes to date, respectively. The Eu complexes, [Eu(HFT)(3)(S-BINAPO)] and [Eu(TFN)(3)(S-BINAPO)] are found to be spontaneously emissive, showing bright red emission, when placed in sunlight or even in the laboratory when light is switched on. (c) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2008.03.093
• 作为产物：
  描述：

  2-萘乙酮 、 庚氟丁酸乙酯 在 petroleum ether 作用下， 生成 4,4,5,5,6,6,6-heptafluoro-1-(2-naphthyl)-1,3-hexanedione
  参考文献：
  名称：

  Dissociative fluorescence enhancement assay

  摘要：

  本发明涉及一种增强溶液，用于利用镧系离子或其螯合物作为标记和解离性荧光增强作为检测工具的检测技术，其中所述增强溶液包括式I的β-二酮，其中R1是芳基，可选单取代或多取代，而R2是直链或支链烷基链，具有2至9个碳原子，取代有四个或更多的氟原子。本发明还涉及一种生物亲和力检测，使用镧系离子或其螯合物作为标记和解离性荧光增强作为检测工具，包括使用所述增强溶液。

  公开号：

  US07381567B2

文献信息

• Compositions for use as a signal generation component and methods of using same
  申请人：Craig R. Alan

  公开号：US20060166376A1

  公开（公告）日：2006-07-27

  Compositions suitable for use as signal generation components of an immunoassay, and methods for their use. According to one aspect of the invention, the composition includes a carrier having a coating of an aminodextran and a metal chelate incorporated therein. The metal chelate is present in the amount of at least 0.065 μM per milligram of carrier, and the aminodextran coating density averaging at least about 45 μg per milligram of carrier. In another aspect of the invention, carrier is dyed with a complex having the formula: M (L1) x (L2) y , wherein M is a metal selected from the group consisting of europium, terbium, dysprosium, samarium, osmium and ruthenium; L1 is a ligand selected from the group consisting of DPP, TOPO, TPPO; L2 comprises a ligand having the formula wherein R is one or more substituents, each substituent comprising an electron donating group; n=2−10; x=1−2; and y=2−4.

  适用于作为免疫测定信号发生成分的组合物及其使用方法。根据本发明的一个方面，组合物包括具有氨基右旋糖酐涂层的载体和掺入其中的金属螯合物。金属螯合物的存在量为每毫克载体至少 0.065 μM，氨基右旋糖酐涂层密度平均为每毫克载体至少约 45 μg。在本发明的另一方面，载体用具有以下式子的复合物染色： M (L1) x (L2) y , 其中 M 是选自铕、铽、镝、钐、锇和钌的金属；L1 是选自 DPP、TOPO、TPPO 的配体； L2 包括具有以下式子的配体 其中 R 是一个或多个取代基，每个取代基包括一个电子供体；n=2-10；x=1-2；y=2-4。
• DISSOCIATIVE FLUORESCENCE ENHANCEMENT ASSAY
  申请人：WALLAC OY

  公开号：EP1483582A1

  公开（公告）日：2004-12-08
• COMPOSITIONS FOR USE AS A SIGNAL GENERATION COMPONENT AND METHODS OF USING SAME
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：EP1856529B1

  公开（公告）日：2012-07-25
• IMMUNOASSAYS EMPLOYING NON-PARTICULATE CHEMILUMINESCENT REAGENT
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：EP2406630B1

  公开（公告）日：2018-01-17
• STABILIZATION OF SIGNAL GENERATION IN PARTICLES USED IN ASSAYS
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：EP2491093B1

  公开（公告）日：2018-11-28