28-acetylprecandidaspongiolide A | 1311277-61-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: 28-acetylprecandidaspongiolide A
• CAS: 1311277-61-8
• 化学式: C₃₄H₅₂O₁₄
• 分子量: 684.778
• InChiKey: XBBJFJWPGLALAQ-FHCWIISNSA-N

反应信息

• 作为产物：
  描述：

  7-deacetylcandidaspongiolide A 、 乙酰氯 在 2,4,6-三甲基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 22.0h， 以41%的产率得到28-acetylprecandidaspongiolide A
  参考文献：
  名称：

  New Candidaspongiolides, Tedanolide Analogues That Selectively Inhibit Melanoma Cell Growth

  摘要：

  Extracts of the sponge genus Candidaspongia showed selective cytotoxicity toward melanoma cells in the NCI 60-cell-line screen. Continued investigation of the Candidaspongia sp. extracts led to the isolation of three new tedanolide analogues, precandidaspongiolides A (1) and B (2) and candidaspongiolide B (4), as well as candidaspongiolide A (3) and tedanolide (5). Semisynthetic derivatives were also generated to develop SAR. Candidaspongiolides A/B were the most potent and showed low nanomolar activity against several melanoma cell lines.

  DOI：

  10.1021/ol201329p