S-(N-4-chlorophenyl-N-hydroxycarbamoyl) butyl sulfoxide | 853754-68-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: S-(N-4-chlorophenyl-N-hydroxycarbamoyl) butyl sulfoxide
• 英文别名: 1-butylsulfinyl-N-(4-chlorophenyl)-N-hydroxyformamide
• CAS: 853754-68-4
• 化学式: C₁₁H₁₄ClNO₃S
• 分子量: 275.756
• InChiKey: SNCIWTSAAQAHGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  76.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] MACROMOLECULAR GSH-ACTIVATED GLYOXYLASE I INHIBITORS<br/>[FR] INHIBITEURS DE GLYOXYLASE I MACROMOLECULAIRES ACTIVES PAR LE GLUTATHION (GSH)
  申请人：UNIV MARYLAND

  公开号：WO2005115338A2

  公开（公告）日：2005-12-08

  This invention relates to macromolecular prodrugs having antitumor activity when activated by GSH, and methods for synthesizing and administering these to patients. More particularly, this invention relates to, inter alia, the synthesis and use of polyacrylamide carriers to target anticancer prodrugs to tumors, and to release active antitumor agents selectively in tumor cells. These active antitumor agents target the active site of the methylglyoxal-detoxifying enzyme glyoxalase I to thereby cause tumor regression.