(2-chloro-4-fluorophenyl)methyl amidinoisothiourea hydrochloride | 1211527-77-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-chloro-4-fluorophenyl)methyl amidinoisothiourea hydrochloride
• 英文别名: (2-chloro-4-fluorophenyl)methyl N-(diaminomethylidene)carbamimidothioate;hydrochloride
• CAS: 1211527-77-3
• 化学式: C₉H₁₀ClFN₄S*ClH
• 分子量: 297.184
• InChiKey: YPKFBSIMDRGTHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.34
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  114
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  脒基硫脲 、 2-氯-4-氟苄氯 以 乙醇 为溶剂， 反应 0.25h， 以75%的产率得到(2-chloro-4-fluorophenyl)methyl amidinoisothiourea hydrochloride
  参考文献：
  名称：

  [EN] COMPOUNDS FOR INHIBITING CELL PROLIFERATION
  [FR] INHIBITION DE LA PROLIFÉRATION CELLULAIRE

  摘要：

  公开号：

  WO2010025448A3

文献信息

• INHIBITION OF CELL PROLIFERATION
  申请人：Sebti Said M.

  公开号：US20100184851A1

  公开（公告）日：2010-07-22

  Compounds of formula (I) and (II) are provided as modulators of Rb:Raf-1 interactions which are potent, selective disruptors of Rb:Raf-1 binding. Therapeutic methods of using the compounds, for example for treating or ameliorating a cell proliferation disorder such as cancer, are provided.
• [EN] INHIBITION OF CELL PROLIFERATION<br/>[FR] INHIBITION DE LA PROLIFÉRATION CELLULAIRE
  申请人：UNIV SOUTH FLORIDA

  公开号：WO2010025448A2

  公开（公告）日：2010-03-04

  Compounds of formula (I) and (II) are provided as modulators of Rb:Raf-1 interactions which are potent, selective disruptors of Rb:Raf-1 binding. Therapeutic methods of using the compounds, for example for treating or ameliorating a cell proliferation disorder such as cancer, are provided.