2-Phenylmethoxyoxepane | 135677-24-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: 2-Phenylmethoxyoxepane
• CAS: 135677-24-6
• 化学式: C₁₃H₁₈O₂
• 分子量: 206.285
• InChiKey: GIJJDGNSEXZFAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Phenylmethoxyoxepane 在 2,4,6-三甲基吡啶 、 三乙基硅基三氟甲磺酸酯 、 水 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以65%的产率得到苯甲醇
  参考文献：
  名称：

  Mild and Efficient Deprotection of Acetal-Type Protecting Groups of Hydroxyl Functions by Triethylsilyl Triflate — 2,4,6-Collidine Combination

  摘要：

  Deprotection of acetal-type protecting groups of hydroxyl functions has been studied in detail. The treatment of alcohol derivatives protected by acetal-type protecting groups with TESOTf-2,4,6-collidine followed by H(2)O-treatment produces the corresponding hydroxyl compounds in good yields. The characteristic features of the method are very mild and chemoselective, and acid-labile functional groups can tolerate these conditions.

  DOI：

  10.3987/com-08-s(f)88
• 作为产物：
  描述：

  2-oxepanol 、 苯甲醇 在 4-甲基苯磺酸吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 2-Phenylmethoxyoxepane
  参考文献：
  名称：

  Mild and Efficient Deprotection of Acetal-Type Protecting Groups of Hydroxyl Functions by Triethylsilyl Triflate — 2,4,6-Collidine Combination

  摘要：

  Deprotection of acetal-type protecting groups of hydroxyl functions has been studied in detail. The treatment of alcohol derivatives protected by acetal-type protecting groups with TESOTf-2,4,6-collidine followed by H(2)O-treatment produces the corresponding hydroxyl compounds in good yields. The characteristic features of the method are very mild and chemoselective, and acid-labile functional groups can tolerate these conditions.

  DOI：

  10.3987/com-08-s(f)88

文献信息

• 1-Tosloxy-2,2-ethylenedioxy-6,10-dimethyl undecanes and undecenes, process for the preparation of 2S*,3R*-3-benzyloxy-6,6-ethylene dioxy-2-methyl-2-(5'-hydroxy-4'-methylpentyl)-oxepane, and use of the latter for the preparation of oxepan-3-ol derivatives
  申请人：ORTHO PHARMACEUTICAL CORPORATION

  公开号：EP0012622B1

  公开（公告）日：1982-12-15
• US4188328A
  申请人：——

  公开号：US4188328A

  公开（公告）日：1980-02-12
• US4256558A
  申请人：——

  公开号：US4256558A

  公开（公告）日：1981-03-17
• US4256644A
  申请人：——

  公开号：US4256644A

  公开（公告）日：1981-03-17
• Mild and Efficient Deprotection of Acetal-Type Protecting Groups of Hydroxyl Functions by Triethylsilyl Triflate — 2,4,6-Collidine Combination
  作者：Hiromichi Fujioka、Yasuyuki Kita、Ozora Kubo、Kazuhisa Okamoto、Kento Senami、Takashi Okitsu、Yoshinari Sawama

  DOI：10.3987/com-08-s(f)88

  日期：——

  Deprotection of acetal-type protecting groups of hydroxyl functions has been studied in detail. The treatment of alcohol derivatives protected by acetal-type protecting groups with TESOTf-2,4,6-collidine followed by H(2)O-treatment produces the corresponding hydroxyl compounds in good yields. The characteristic features of the method are very mild and chemoselective, and acid-labile functional groups can tolerate these conditions.