4-bromobenzaldoxime O-methyl ether | 33581-31-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-bromobenzaldoxime O-methyl ether
• 英文别名: 4-bromobenzaldehyde methyl oxime；Benzaldehyde, p-bromo-, O-methyloxime；(E)-1-(4-bromophenyl)-N-methoxymethanimine
• CAS: 33581-31-6
• 化学式: C₈H₈BrNO
• 分子量: 214.062
• InChiKey: USDSGWSDNSYHRQ-UXBLZVDNSA-N

物化性质

• 沸点：
  243.9±42.0 °C(Predicted)
• 密度：
  1.37±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  乙醇 、 4-bromobenzaldoxime O-methyl ether 在 2-硝基苯硒酸 、 双氧水 作用下， 反应 50.0h， 以82%的产率得到4-溴苯甲酸乙酯
  参考文献：
  名称：

  Oxidative Conversion of Aldoximes into Carboxylic Acid Esters

  摘要：

  Aromatic and aliphatic aldoximes or their O-methyl ethers can be efficiently converted into the corresponding carboxylic acid esters by treatment with an alcoholic solution of 30% hydrogen peroxide in the Presence of catalytic amounts of 2-nitrobenzeneseleninic acid. Primary alcohols give excellent to good yields, secondary ones - good to moderate, but with tertiary alcohols no esterification is obserwed.

  DOI：

  10.1080/00397919208021316
• 作为产物：
  描述：

  4-bromobenzaldehyde oxime 、 碘甲烷 在 sodium 作用下， 生成 4-bromobenzaldoxime O-methyl ether
  参考文献：
  名称：

  Oxidative Conversion of Aldoximes into Carboxylic Acid Esters

  摘要：

  Aromatic and aliphatic aldoximes or their O-methyl ethers can be efficiently converted into the corresponding carboxylic acid esters by treatment with an alcoholic solution of 30% hydrogen peroxide in the Presence of catalytic amounts of 2-nitrobenzeneseleninic acid. Primary alcohols give excellent to good yields, secondary ones - good to moderate, but with tertiary alcohols no esterification is obserwed.

  DOI：

  10.1080/00397919208021316

文献信息

• Pyrazolyl biphenyl carboxamides and the use thereof for controlling undesired microorganisms
  申请人：——

  公开号：US20040053971A1

  公开（公告）日：2004-03-18

  Novel pyrazolylbiphenylcarboxamides of the formula (I) 1 in which R 1 , R 2 , X, m, Y and n are each as defined in the description, a plurality of processes for preparing these substances and their use for controlling undesirable microorganisms, and also novel intermediates and their preparation.

  化合物的新颖吡唑基联苯甲酰胺的化学式（I），其中R1、R2、X、m、Y和n的定义如描述中所述，以及用于制备这些物质和控制不良微生物的多种过程，还有新颖的中间体及其制备。
• 一种O-/N-烷基取代羟胺盐的制备方法
  申请人：诚弘制药（威海）有限责任公司

  公开号：CN113636953A

  公开（公告）日：2021-11-12

  本发明涉及一种N‑/O‑烷基取代羟胺盐的制备方法，属于精细化工、农药或原料药化工技术领域。本发明以肟的N‑/O‑烷基化物与羟胺无机盐反应，生成N‑/O‑烷基取代羟胺无机盐和肟。本发明通过前所未有的羟胺交换发明，提供一种高效、环保制备N‑/O‑烷基取代羟胺盐的方法，制备N‑/O‑烷基取代羟胺无机盐的同时，肟可经重新制备生成肟的N‑/O‑烷基化物，实现物料循环；反应过程无需使用当量的酸、碱中和，避免了现行方法使用大量酸、碱和产生无机盐固废缺点，更加绿色环保。而且所述的制备方法反应条件温和，避免了传统工艺高污染、高耗能的缺点。其中，R1、R2、R如权利要求和说明书所述。
• Diaryliodoniums by Rhodium(III)-Catalyzed CH Activation: Mild Synthesis and Diversified Functionalizations
  作者：Fang Xie、Zhipeng Zhang、Xinzhang Yu、Guodong Tang、Xingwei Li

  DOI：10.1002/anie.201502278

  日期：2015.6.15

  Diaryliodonium salts play an increasingly important role as an aryl source. Reported is the first synthesis of diaryliodoniums by rhodium(III)‐catalyzed CH hyperiodination of electron‐poor arenes under chelation assistance. This CI coupling reaction occurred at room temperature with high regio‐selectivity and functional‐group compatibility. Subsequent diversified nucleophilic functionalization of

  二芳基碘鎓盐作为芳基源发挥着越来越重要的作用。报道是由铑diaryliodoniums的第一合成（III）催化Ç 轰下螯合援助贫电子芳烃的hyperiodination。这种CI偶联反应在室温下具有较高的区域选择性和官能团相容性。随后对二芳基碘的多样化亲核官能化使得可以容易地构建CC，CN，CO，CS，CP和CBr键，并且在所有情况下，初始功能化均发生在含有螯合剂的芳烃上-团体。
• Pyrazolyl biphenyl carboxamides and the use thereof for controlling undesirable microorganisms
  申请人：Elbe Hans-Ludwig

  公开号：US20050182120A1

  公开（公告）日：2005-08-18

  Novel pyrazolylbiphenylcarboxamides of the formula (I) in which R 1 , R 2 , X, m, Y and n are each as defined in the description, a plurality of processes for preparing these substances and their use for controlling undesirable microorganisms, and also novel intermediates and their preparation.

  化合物的式子为(I)，其中R1，R2，X，m，Y和n的定义如描述中所定义，提供了制备这些物质的多种过程以及它们用于控制不良微生物的用途，还提供了新的中间体及其制备方法。
• FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES
  申请人：Beier Christian

  公开号：US20130012546A1

  公开（公告）日：2013-01-10

  The present invention relates to hydroximoyl-tetrazole derivatives of formula (I), their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. wherein A represents a tetrazoyl group, Het represents a pyridyl group or a thiazolyl group and X represents various substituents.

  本发明涉及式（I）的羟肟基四唑衍生物，其制备方法，作为杀真菌活性剂的用途，特别是以杀真菌组合物的形式和使用这些化合物或组合物控制植物病原真菌，尤其是植物的方法。 其中，A代表四唑基团，Het代表吡啶基团或噻唑基团，X代表各种取代基。