(1R,2S)-2-N-Methyl-N-(diphenylphosphino)-2-amino-1-phenyl-1-(diphenylphosphinoxy)propane | 90032-60-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1R,2S)-2-N-Methyl-N-(diphenylphosphino)-2-amino-1-phenyl-1-(diphenylphosphinoxy)propane
• 英文别名: (+)-(1R,2S)-2-[(diphenylphosphino)methylamino]-1-phenylpropyl diphenylphosphinite；(1R,2S)-ephos；L(+)-EPHOS；(1R,2S)-N-diphenylphosphanyl-1-diphenylphosphanyloxy-N-methyl-1-phenylpropan-2-amine
• CAS: 90032-60-3
• 化学式: C₃₄H₃₃NOP₂
• 分子量: 533.59
• InChiKey: KLZQEILSULOPSY-GVYVVWIYSA-N

物化性质

• 沸点：
  646.3±65.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  38
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1R,2S)-2-N-Methyl-N-(diphenylphosphino)-2-amino-1-phenyl-1-(diphenylphosphinoxy)propane 、 三(三苯基膦)羰基氢化铑 以 not given 为溶剂， 生成 RhH(CO)(L(+)-EPHOS)PPh3
  参考文献：
  名称：

  Utilisation des ligands aminophosphinephosphinites en hydroformylation catalysée par le rhodium: amélioration de l'énantioselectivité par synthèse selective des hydrures RhH(CO)2L★2

  摘要：

  DOI：

  10.1016/0022-328x(89)87296-1
• 作为产物：
  描述：

  麻黄碱 、 二苯基氯化膦 在 三乙胺 作用下， 以 甲苯 为溶剂， 生成 (1R,2S)-2-N-Methyl-N-(diphenylphosphino)-2-amino-1-phenyl-1-(diphenylphosphinoxy)propane
  参考文献：
  名称：

  氨基膦次膦酸酯和双（氨基膦）手性配体镍配合物催化丁二烯环二聚反应高选择性合成4-乙烯基环己烯

  摘要：

  氨基膦次膦酸酯和双（氨基膦）手性配体可实现丁二烯在镍配合物上环二聚反应，观察到的最高的4-乙烯基环己烯化学选择性合成（选择性高达99％）。

  DOI：

  10.1016/0040-4039(94)85067-4

文献信息

• Chiral aminophosphine phosphinite–palladium catalysts in asymmetric allylic alkylations
  作者：Liuzhu Gong、Guoshu Chen、Aiqiao Mi、Yaozhong Jiang*、Fangmin Fu、Xin Cui、Albert S.C Chan

  DOI：10.1016/s0957-4166(00)00412-2

  日期：2000.11

  Palladium complexes of chiral aminophosphine phosphinites were investigated for the asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate with dimethyl malonate. The chirality of the carbon bonded to O-PPh2 in the ligands was found to be very important to the enantioselectivity of the catalysts. Introduction of this stereogenic center has led to significantly improved enantioselectivities. (C) 2000 Elsevier Science Ltd. All rights reserved.
• New 1,2-aminoalcohol derivative ligands of rhodium asymmetric hydrogenation catalysts
  作者：V. A. Pavlov、N. I. Spitsyna、A. A. Voloboev、L. S. Gorshkova、�. P. Serebryakov、E. I. Klabunovskii

  DOI：10.1007/bf00995733

  日期：1984.3
• Application of P-Stereogenic Aminophosphine Phosphinite Ligands in Asymmetric Hydroformylation
  作者：Regine Ewalds、Eva B. Eggeling、Alison C. Hewat、Paul C. J. Kamer、Piet W. N. M. van Leeuwen、Dieter Vogt

  DOI：10.1002/(sici)1521-3765(20000417)6:8<1496::aid-chem1496>3.0.co;2-8

  日期：2000.4.17

  New chiral aminophosphine phosphinite ligands with a stereogenic center at the aminophosphine phosphorus atom were prepared based on (R,S)-ephedrine as the chiral auxiliary and backbone. Substituents at the chiral aminophosphine as well as at the phosphinite phosphorus atom were varied. These new ligands were applied to the rhodium-catalyzed asymmetric hydroformylation of vinyl arenes, The enantiomeric excess reached up to 77%. H-1 and P-31 NMR studies of the Rh complexes under syngas pressure reveal that [HRh(CO)(2)((PP)-P-boolean AND)] complexes with the NP* moiety in an axial position are responsible for enantioselectivity.
• A new optically pure half-sandwich Cp–Ru diphosphine complex with a chiral metal centre, (<i>S</i>)-Ru(η⁵-C₅H₅)(EPHOS)Cl {EPHOS is (+)-(1<i>R</i>,2<i>S</i>)-2-[(diphenylphosphino)methylamino]-1-phenylpropyl diphenylphosphinite}
  作者：Pierre Haquette、Franck Lebideau、Samuel Dagorne、Jérôme Marrot、Gérard Jaouen

  DOI：10.1107/s0108270102018395

  日期：2002.11.15

  The crystal structure of the title compound, chloro(eta(5)-cyclopentadienyl)(1R,2S)-2-[(diphenylphosphino)methylamino]-1-phenylpropyl diphenylphosphinite-kappa(2) P,P'}ruthenium(II), [Ru(C5H5)Cl(C34H33NOP2)], is reported. The pseudo-octahedral complex is chiral and the configuration at the Ru atom is S. The seven-membered metallacycle adopts a boat-like conformation.