4-(2,2,6,6-tetramethyltetrahydropyran-4-yl)benzene-1,3-diol | 1228321-09-2

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 4-(2,2,6,6-tetramethyltetrahydropyran-4-yl)benzene-1,3-diol
• 英文别名: 4-(2,2,6,6-Tetramethyloxan-4-yl)benzene-1,3-diol
• CAS: 1228321-09-2
• 化学式: C₁₅H₂₂O₃
• 分子量: 250.338
• InChiKey: BZYRGBLLQUNNMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] NOVEL 4-(HETEROCYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND ALSO IN COSMETICS<br/>[FR] NOUVEAUX COMPOSÉS DE 4- (HÉTÉROCYCLOALKYL)BENZÈNE-1,3-DIOL UTILISÉS COMME INHIBITEURS DE LA TYROSINASE, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION EN MÉDECINE HUMAINE ET DANS LES COSMÉTIQUES
  申请人：GALDERMA RES & DEV

  公开号：WO2010063773A1

  公开（公告）日：2010-06-10

  The present invention relates to novel 4- (heterocycloalkyl) benzene- 1, 3-diol compounds corresponding to general formula (I) below: to the compositions containing same, to the process for the preparation thereof and to the use thereof in pharmaceutical or cosmetic compositions for use in the treatment or prevention of pigmentary disorders.

  本发明涉及与下面的一般式（I）对应的新型4-（杂环烷基）苯-1,3-二酚化合物，以及含有该化合物的组合物，其制备过程以及在用于治疗或预防色素紊乱的制药或化妆品组合物中的应用。
• 4-(HETEROCYCLOALKYL) BENZENE -1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND ALSO IN COSMETICS
  申请人：Boiteau Jean-Guy

  公开号：US20120041213A1

  公开（公告）日：2012-02-16

  4-(heterocycloalkyl)benzene-1,3-diol compounds are described corresponding to general formula (I) below: Also described, are compositions including the same, processes for preparation thereof and to the use thereof in pharmaceutical or cosmetic compositions for use in the treatment or prevention of pigmentary disorders.

  本文描述了符合以下通式（I）的4-（杂环烷基）苯-1,3-二酚化合物：同时还描述了包括这些化合物的组合物，其制备过程以及在制备用于治疗或预防色素性疾病的药物或化妆品组合物中使用它们的用途。
• Novel 4-(heterocycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics
  申请人：Galderma Research & Development

  公开号：EP2529735A1

  公开（公告）日：2012-12-05

  The present invention relates to novel 4-(heterocycloalkyl)benzene-1,3-diol compounds corresponding to general formula (I) below: to the compositions containing same, to the process for the preparation thereof and to the use thereof in pharmaceutical or cosmetic compositions for use in the treatment or prevention of pigmentary disorders.

  本发明涉及如下通式(I)对应的新型 4-(杂环烷基)苯-1,3-二醇化合物： 本发明涉及含有这些化合物的组合物、其制备工艺以及其在治疗或预防色素性疾病的药物或化妆品组合物中的用途。
• NOVEL 4-(HETEROCYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND ALSO IN COSMETICS
  申请人：Galderma Research & Development

  公开号：EP2373310A1

  公开（公告）日：2011-10-12
• COMPOSITIONS COMPRISING 4-(HETEROCYCLOALKYL)BENZENE-1,3-DIOL DERIVATIVES WITH TYROSINASE ENZYME INHIBITING ACTIVITY
  申请人：Galderma Research & Development

  公开号：EP2529735B1

  公开（公告）日：2014-06-25