tetraaquabis(N-phthaloylglycinato)nickel(II) hydrate | 1416910-59-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: tetraaquabis(N-phthaloylglycinato)nickel(II) hydrate
• 英文别名: [Ni(NPG)₂(H₂O)₄]H₂O
• CAS: 1416910-59-2
• 化学式: C₂₀H₂₀N₂NiO₁₂*H₂O
• 分子量: 557.09
• InChiKey: AEJBXDWVNLLIHU-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  nickel(II) acetate tetrahydrate 、 邻苯二甲酰甘氨酸 以 乙醇 、 水 为溶剂， 反应 3.5h， 以75%的产率得到tetraaquabis(N-phthaloylglycinato)nickel(II) hydrate
  参考文献：
  名称：

  Synthesis, crystal structure, DNA binding and in vitro biological studies of Ni(II), Cu(II) and Zn(II) complexes of N-phthaloylglycine

  摘要：

  Ni(II), Cu( II) and Zn(II) metal complexes of N-phthaloylglycine were synthesized, characterized, reported for single crystal X-ray diffraction analysis for Ni(II) complex, and investigated for their binding with DNA under physiological conditions, using spectroscopic (UV-visible and fluorescence) and hydrodynamic techniques. Experimental results from both spectroscopic methods were comparable and further supported by viscosity measurements. Binding constant "K-b" obtained from both spectroscopic methods revealed significant binding of compounds with DNA via intercalation. Among all compounds comparatively good DNA binding was found for Zn(II) complex. Free energies of compounds-DNA interactions indicated spontaneity of their binding. Dynamic and bimolecular enhancement values disclose static process involved in compounds-DNA complex formation. All compounds exhibited broad range antibacterial, while Zn(II) complex exhibited best antitumor activity. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jphotobiol.2012.10.003